Amphotericin B
- Generic Name
- Amphotericin B
- Brand Names
- Abelcet, Ambisome, Amphotec, Fungizone
- Drug Type
- Small Molecule
- Chemical Formula
- C47H73NO17
- CAS Number
- 1397-89-3
- Unique Ingredient Identifier
- 7XU7A7DROE
- Background
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL...
- Indication
Used to treat potentially life threatening fungal infections.
- Associated Conditions
- Coccidioidomycosis, Fungal Infections, Histoplasmosis, Invasive Aspergillosis, Invasive Fungal Infections, Leishmaniasis, Meningitis, Cryptococcal, Meningitis, Fungal, Mucocutaneous Leishmaniasis, Mycotic endophthalmitis, Penicillium marneffei infection, Visceral Leishmaniasis, Candidal cystitis, Disseminated Cryptococcosis, Fungal osteoarticular infections, Ocular aspergillosis, Refractory aspergillosis, Severe Coccidioidomycosis, Severe Cryptococcosis, Severe Fungal infection caused by Basidiobolus spp., Severe Fungal infection caused by Conidiobolus spp., Severe Fungal infection caused by sporotrichosis spp., Severe Histoplasmosis, Severe Mucocutaneous leishmaniasis, Severe North American blastomycosis, Severe Systemic candidiasis
- Associated Therapies
- -
Safety and Effectiveness of Short-course AmBisome in the Treatment of PKDL in Bangladesh
- First Posted Date
- 2017-10-17
- Last Posted Date
- 2017-10-17
- Lead Sponsor
- Medecins Sans Frontieres, Netherlands
- Target Recruit Count
- 280
- Registration Number
- NCT03311607
Treatment With Tamoxifen in Cryptococcal Meningitis
- Conditions
- Interventions
- First Posted Date
- 2017-04-13
- Last Posted Date
- 2019-12-02
- Target Recruit Count
- 50
- Registration Number
- NCT03112031
- Locations
- 🇻🇳
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
🇻🇳Cho Ray Hospital, Ho Chi Minh City, Vietnam
🇻🇳Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis
- First Posted Date
- 2016-02-22
- Last Posted Date
- 2016-02-22
- Lead Sponsor
- Hui Bu
- Target Recruit Count
- 40
- Registration Number
- NCT02686853
CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis
- First Posted Date
- 2015-12-14
- Last Posted Date
- 2024-08-07
- Lead Sponsor
- Matinas BioPharma Nanotechnologies, Inc.
- Target Recruit Count
- 4
- Registration Number
- NCT02629419
- Locations
- 🇺🇸
National Institute of Allergy and Infectious Disease (NIAID), Bethesda, Maryland, United States
Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis
- Conditions
- Interventions
- First Posted Date
- 2014-05-12
- Last Posted Date
- 2014-05-12
- Lead Sponsor
- TTY Biopharm
- Target Recruit Count
- 84
- Registration Number
- NCT02136030
- Locations
- 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
Liposomal Amphotericin in Disseminated Leishmaniasis
- First Posted Date
- 2014-01-01
- Last Posted Date
- 2014-01-01
- Lead Sponsor
- Hospital Universitário Professor Edgard Santos
- Target Recruit Count
- 20
- Registration Number
- NCT02025491
- Locations
- 🇧🇷
HUPES, Salvador, Bahia, Brazil
Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients.
- Conditions
- Interventions
- First Posted Date
- 2013-12-16
- Last Posted Date
- 2019-04-08
- Lead Sponsor
- Drugs for Neglected Diseases
- Target Recruit Count
- 59
- Registration Number
- NCT02011958
- Locations
- 🇪🇹
MSF, Abdurafi, Ethiopia
🇪🇹Leishmaniasis Research Center, University Hospital of Gondar, Gondar, Ethiopia
An Bioequivalence Study to Compare Two 2 mg/ml Liposomal Amphotericin B Injections in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2012-07-30
- Last Posted Date
- 2013-11-27
- Lead Sponsor
- Taiwan Liposome Company
- Target Recruit Count
- 36
- Registration Number
- NCT01652859
Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia
- Conditions
- Interventions
- First Posted Date
- 2012-06-11
- Last Posted Date
- 2018-03-29
- Lead Sponsor
- Fundació Sant Joan de Déu
- Target Recruit Count
- 32
- Registration Number
- NCT01615809
- Locations
- 🇪🇸
Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Single Dose Liposomal Amphotericin B for Visceral Leishmaniasis
- First Posted Date
- 2012-03-29
- Last Posted Date
- 2014-01-22
- Lead Sponsor
- Banaras Hindu University
- Target Recruit Count
- 1300
- Registration Number
- NCT01566552
- Locations
- 🇮🇳
Kala Azar Medical Research Center, Muzaffarpur, Bihar, India
Drug Development Updates
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