Amphotericin B

Generic Name: Amphotericin B

Brand Names: Abelcet, Ambisome, Amphotec, Fungizone

Drug Type: Small Molecule

Chemical Formula: C_₄₇H_₇₃NO_₁₇

CAS Number: 1397-89-3

Unique Ingredient Identifier: 7XU7A7DROE

Background: Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL...

Indication: Used to treat potentially life threatening fungal infections.

Associated Conditions: Coccidioidomycosis, Fungal Infections, Histoplasmosis, Invasive Aspergillosis, Invasive Fungal Infections, Leishmaniasis, Meningitis, Cryptococcal, Meningitis, Fungal, Mucocutaneous Leishmaniasis, Mycotic endophthalmitis, Penicillium marneffei infection, Visceral Leishmaniasis, Candidal cystitis, Disseminated Cryptococcosis, Fungal osteoarticular infections, Ocular aspergillosis, Refractory aspergillosis, Severe Coccidioidomycosis, Severe Cryptococcosis, Severe Fungal infection caused by Basidiobolus spp., Severe Fungal infection caused by Conidiobolus spp., Severe Fungal infection caused by sporotrichosis spp., Severe Histoplasmosis, Severe Mucocutaneous leishmaniasis, Severe North American blastomycosis, Severe Systemic candidiasis

Associated Therapies: -

Clinical Trials

Single Infusion of Liposomal Amphotericin B in Indian Visceral Leishmaniasis

Phase 3

Completed

Conditions: Visceral Leishmaniasis

Interventions: Drug: Liposomal Amphotericin B
Drug: amphotericin B deoxycholate

First Posted Date: 2008-03-05

Last Posted Date: 2009-04-03

Lead Sponsor: Banaras Hindu University

Target Recruit Count: 400

Registration Number: NCT00628719

Locations: 🇮🇳
Kala-azar Medical Research Center, Rambag Road, Muzaffarpur, India

Antimicrobial PK in Infants With Suspected or Confirmed Infection

Completed

Conditions: Infection

Interventions: Drug: Ampicillin
Drug: Metronidazole
Drug: Piperacillin/Tazobactam
Drug: Acyclovir
Drug: Amphotericin B
Drug: Ambisome
Drug: Anidulafungin
Drug: Caspofungin

First Posted Date: 2007-06-26

Last Posted Date: 2012-11-19

Lead Sponsor: Duke University

Target Recruit Count: 450

Registration Number: NCT00491426

Locations: 🇺🇸
Children's National Medical Center, Washington, District of Columbia, United States
🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸
University of California at San Diego, La Jolla, California, United States

and more 3 locations

Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment

Phase 2

Completed

Conditions: Zygomycosis

Interventions: Drug: Liposomal Amphotericin B

First Posted Date: 2007-05-01

Last Posted Date: 2014-07-18

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 40

Registration Number: NCT00467883

Locations: 🇫🇷
Hôpital Necker - Service des Maladies Infectieuses et Tropicales, Paris, France
🇫🇷
Necker Hospital, Paris, France

Intermittent Liposomal Amphotericin B Primary Prophylaxis

Phase 2

Conditions: Acute Myeloid Leukemia

First Posted Date: 2007-03-23

Last Posted Date: 2013-12-16

Lead Sponsor: Bayside Health

Target Recruit Count: 60

Registration Number: NCT00451711

Locations: 🇦🇺
The Alfred Hosptial, Melbourne, Victoria, Australia
🇦🇺
Box Hill Hospital, Eastern Health, Melbourne, Victoria, Australia

The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study

Phase 2

Completed

Conditions: Mucormycosis

Interventions: Drug: deferasirox
Drug: Placebo
Drug: Liposomal amphotericin B

First Posted Date: 2007-01-09

Last Posted Date: 2023-10-16

Lead Sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Target Recruit Count: 20

Registration Number: NCT00419770

Locations: 🇺🇸
UCSF, San Francisco, California, United States
🇺🇸
Duke University, Durham, North Carolina, United States
🇺🇸
City of Hope National Medical Center, Duarte, California, United States

and more 4 locations