Amphotericin B

Generic Name: Amphotericin B

Brand Names: Abelcet, Ambisome, Amphotec, Fungizone

Drug Type: Small Molecule

Chemical Formula: C_₄₇H_₇₃NO_₁₇

CAS Number: 1397-89-3

Unique Ingredient Identifier: 7XU7A7DROE

Background: Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL...

Indication: Used to treat potentially life threatening fungal infections.

Associated Conditions: Coccidioidomycosis, Fungal Infections, Histoplasmosis, Invasive Aspergillosis, Invasive Fungal Infections, Leishmaniasis, Meningitis, Cryptococcal, Meningitis, Fungal, Mucocutaneous Leishmaniasis, Mycotic endophthalmitis, Penicillium marneffei infection, Visceral Leishmaniasis, Candidal cystitis, Disseminated Cryptococcosis, Fungal osteoarticular infections, Ocular aspergillosis, Refractory aspergillosis, Severe Coccidioidomycosis, Severe Cryptococcosis, Severe Fungal infection caused by Basidiobolus spp., Severe Fungal infection caused by Conidiobolus spp., Severe Fungal infection caused by sporotrichosis spp., Severe Histoplasmosis, Severe Mucocutaneous leishmaniasis, Severe North American blastomycosis, Severe Systemic candidiasis

Associated Therapies: -

Clinical Trials

Safety and Efficacy Study of Paromomycin to Treat Visceral Leishmaniasis

Phase 3

Completed

Conditions: Visceral Leishmaniasis

First Posted Date: 2005-09-22

Last Posted Date: 2014-10-03

Lead Sponsor: PATH

Target Recruit Count: 667

Registration Number: NCT00216346

Locations: 🇮🇳
Rajendra Memorial Research Institute of Medical Sciences (ICMR), Agam Kuan, Patna, Bihar, India
🇮🇳
Kalazar Research Centre, Patna, Bihar, India
🇮🇳
Kala-azar Medical Research Centre, Rambagh Road Muzaffarpur, Bihar, India

Comparison of 2 Antifungal Treatment (Empirical Versus Pre-Empirical) Strategies in Prolonged Neutropenia

Phase 4

Terminated

Conditions: Malignant Hemopathy
Duration of Neutropenia Following Chemotherapy > 10 Days

First Posted Date: 2005-09-19

Last Posted Date: 2006-09-21

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 300

Registration Number: NCT00190463

Locations: 🇫🇷
Chu Henri Mondor, Paris, Ile de France, France

Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study

Phase 3

Completed

Conditions: Lung Transplantation
Fungal Infections

First Posted Date: 2005-09-15

Last Posted Date: 2008-12-17

Lead Sponsor: University of Pittsburgh

Target Recruit Count: 48

Registration Number: NCT00177710

Locations: 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®)

Phase 3

Completed

Conditions: Lung Transplantation
Fungal Infections

First Posted Date: 2005-09-15

Last Posted Date: 2008-12-17

Lead Sponsor: University of Pittsburgh

Target Recruit Count: 48

Registration Number: NCT00177684

Locations: 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment

Phase 3

Completed

Conditions: Invasive Aspergillosis
Other Fungal Infections

First Posted Date: 2005-09-12

Last Posted Date: 2005-11-18

Lead Sponsor: Gilead Sciences

Target Recruit Count: 800

Registration Number: NCT00158730

Ambisome in Liver Transplant Patients

Phase 4

Terminated

Conditions: Liver Transplantation

First Posted Date: 2005-09-12

Last Posted Date: 2008-06-23

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 10

Registration Number: NCT00161356

Locations: 🇺🇸
Memorial Hermann Hospital, Houston, Texas, United States

A Study of Caspofungin, Liposomal Amphotericin B or the Combination of Both for Patients After Stem-Cell Transplantation

Phase 2

Completed

Conditions: Hematopoietic Stem Cell Transplantation
Fungus Diseases

First Posted Date: 2005-09-07

Last Posted Date: 2008-01-16

Lead Sponsor: University Hospital Muenster

Target Recruit Count: 75

Registration Number: NCT00148148

Locations: 🇩🇪
KKS Münster University Hospital, Münster, NRW, Germany

Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis

Phase 2

Completed

Conditions: Cryptococcal Meningitis

Interventions: Drug: Amphotericin B
Drug: Fluconazole

First Posted Date: 2005-09-05

Last Posted Date: 2012-05-16

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 143

Registration Number: NCT00145249

Locations: 🇺🇸
University of Southern California, Los Angeles, California, United States
🇺🇸
Harbor-UCLA Medical Center, Los Angeles, California, United States
🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

and more 12 locations