Amphotericin B

Generic Name
Amphotericin B
Brand Names
Abelcet, Ambisome, Amphotec, Fungizone
Drug Type
Small Molecule
Chemical Formula
C47H73NO17
CAS Number
1397-89-3
Unique Ingredient Identifier
7XU7A7DROE
Background

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL...

Indication

Used to treat potentially life threatening fungal infections.

Associated Conditions
Coccidioidomycosis, Fungal Infections, Histoplasmosis, Invasive Aspergillosis, Invasive Fungal Infections, Leishmaniasis, Meningitis, Cryptococcal, Meningitis, Fungal, Mucocutaneous Leishmaniasis, Mycotic endophthalmitis, Penicillium marneffei infection, Visceral Leishmaniasis, Candidal cystitis, Disseminated Cryptococcosis, Fungal osteoarticular infections, Ocular aspergillosis, Refractory aspergillosis, Severe Coccidioidomycosis, Severe Cryptococcosis, Severe Fungal infection caused by Basidiobolus spp., Severe Fungal infection caused by Conidiobolus spp., Severe Fungal infection caused by sporotrichosis spp., Severe Histoplasmosis, Severe Mucocutaneous leishmaniasis, Severe North American blastomycosis, Severe Systemic candidiasis
Associated Therapies
-

A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Pfizer
Registration Number
NCT00002277
Locations
🇺🇸

Dr Temple Williams, Houston, Texas, United States

🇺🇸

M D Anderson Cancer Ctr, Houston, Texas, United States

🇺🇸

Dr Layne Gentry, Houston, Texas, United States

Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Pfizer
Registration Number
NCT00002074
Locations
🇺🇸

Dr Richard Meyer, Los Angeles, California, United States

🇺🇸

DeKalb Gen Hosp, Decatur, Georgia, United States

🇺🇸

Shallowford Hosp, Decatur, Georgia, United States

and more 36 locations

A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Pfizer
Registration Number
NCT00002068
Locations
🇺🇸

Christiana Hosp / Med Ctr of Delaware, Wilmington, Delaware, United States

🇺🇸

Univ of Tennessee, Memphis, Tennessee, United States

🇺🇸

Davies Med Ctr, San Francisco, California, United States

and more 5 locations

Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants

Phase 4
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2010-08-27
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
500
Registration Number
NCT00001107
Locations
🇺🇸

Mary Ellen Bradley, Birmingham, Alabama, United States

Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2011-03-14
Lead Sponsor
Pfizer
Target Recruit Count
330
Registration Number
NCT00001017
Locations
🇺🇸

Beth Israel Deaconess - West Campus, Boston, Massachusetts, United States

🇺🇸

SUNY - Stony Brook, Stony Brook, New York, United States

🇺🇸

Duke Univ Med Ctr, Durham, North Carolina, United States

and more 25 locations

Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2011-03-14
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
120
Registration Number
NCT00000708
Locations
🇺🇸

Univ of Miami School of Medicine, Miami, Florida, United States

🇺🇸

Julio Arroyo, West Columbia, South Carolina, United States

🇺🇸

Tulane Univ School of Medicine, New Orleans, Louisiana, United States

and more 3 locations

A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis

First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Janssen, LP
Target Recruit Count
60
Registration Number
NCT00002159
Locations
🇺🇸

Community Hosp, Indianapolis, Indiana, United States

🇺🇸

LSU Med Ctr / Div of Pulmonary & Critical Care Med, Shreveport, Louisiana, United States

🇺🇸

Univ of Arkansas for Med Sciences, Little Rock, Arkansas, United States

and more 6 locations

Evaluation of Amphotericin B in the Treatment of Biopsy Proven Candida Esophagitis in Immunocompromised Patients

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2007-10-02
Lead Sponsor
Bristol-Myers Squibb
Registration Number
NCT00002041
Locations
🇺🇸

Bristol - Myers Squibb Co, Princeton, New Jersey, United States

Dexamethasone in Cryptococcal Meningitis

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-28
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
36
Registration Number
NCT00000776
Locations
🇺🇸

Northwestern Univ Med School, Chicago, Illinois, United States

🇺🇸

Cook County Hosp, Chicago, Illinois, United States

🇺🇸

Univ of Miami School of Medicine, Miami, Florida, United States

and more 11 locations

Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2009-06-03
Lead Sponsor
InterMune
Target Recruit Count
60
Registration Number
NCT00012467
Locations
🇺🇸

Houston Veterans Administration Med Ctr, Houston, Texas, United States

🇺🇸

Univ of Texas / Med School at Houston, Houston, Texas, United States

🇵🇪

Instituto de Medicina Tropical, Lima, Peru

and more 6 locations
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