Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

Vitamin D Supplementation for Treatment of Heart Failure

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2010-10-29
Last Posted Date
2016-11-18
Lead Sponsor
University of Michigan
Target Recruit Count
28
Registration Number
NCT01230307
Locations
🇺🇸

University of Michigan Medical Center, Ann Arbor, Michigan, United States

Efficacy of Vitamin D on Top of Pegylated Interferon and Ribavirin in Patients With Chronic Viral Hepatitis C Null-Responders

Phase 2
Completed
Conditions
Interventions
First Posted Date
2010-10-22
Last Posted Date
2014-08-11
Lead Sponsor
French National Agency for Research on AIDS and Viral Hepatitis
Target Recruit Count
32
Registration Number
NCT01226446
Locations
🇫🇷

Hôpital Pitié Salpêtrière, Paris, France

Hemodialysis Vitamin D Pilot

First Posted Date
2010-10-05
Last Posted Date
2011-07-20
Lead Sponsor
St. Joseph's Healthcare Hamilton
Target Recruit Count
20
Registration Number
NCT01214928
Locations
🇨🇦

St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada

Vitamin D in Bronchiolitis Obliterans Syndrome

First Posted Date
2010-09-30
Last Posted Date
2015-11-11
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
100
Registration Number
NCT01212406
Locations
🇧🇪

UZ Gasthuisberg, Leuven, Belgium

Use of Vitamin D3 for the Treatment of Steroid Resistant Asthmatic Patients

Phase 2
Withdrawn
Conditions
Interventions
First Posted Date
2010-09-28
Last Posted Date
2016-08-10
Lead Sponsor
Florida Atlantic University
Registration Number
NCT01210521

Vitamin D Supplementation in CAD and Postchallenge Hyperglycemia

First Posted Date
2010-08-17
Last Posted Date
2015-04-17
Lead Sponsor
Medical University of Graz
Target Recruit Count
22
Registration Number
NCT01183442
Locations
🇦🇹

Dept. of Internal Medicine, Medical University of Graz, Graz, Austria

Vitamin D for Treatment of Glioblastoma Multiforme

Phase 1
Conditions
First Posted Date
2010-08-13
Last Posted Date
2011-03-29
Lead Sponsor
Soroka University Medical Center
Target Recruit Count
20
Registration Number
NCT01181193
Locations
🇮🇱

Soroka University Medical Center, Beer Sheva, Israel

VItamin D Effect on Osteoarthritis Study

Phase 3
Completed
Conditions
Interventions
First Posted Date
2010-08-06
Last Posted Date
2015-09-09
Lead Sponsor
Menzies Institute for Medical Research
Target Recruit Count
413
Registration Number
NCT01176344
Locations
🇦🇺

Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia

🇦🇺

Department of Epidemiology & Preventive Medicine, Monash University, Melbourne, Victoria, Australia

Impact of Vitamin D Repletion in Hemodialysis Patients

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2010-08-05
Last Posted Date
2014-09-22
Lead Sponsor
Mehrotra, Anita, M.D.
Target Recruit Count
116
Registration Number
NCT01175798
Locations
🇺🇸

Mount Sinai School of Medicine, New York, New York, United States

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