Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study

First Posted Date
2011-03-25
Last Posted Date
2011-04-19
Lead Sponsor
Weill Medical College of Cornell University
Target Recruit Count
40
Registration Number
NCT01323608
Locations
🇺🇸

Weill Cornell Medical College, New York, New York, United States

Vitamin D3 Supplementation in Dialysis Patients

Phase 2
Completed
Conditions
Interventions
First Posted Date
2011-03-11
Last Posted Date
2013-05-29
Lead Sponsor
Regional Hospital Holstebro
Target Recruit Count
64
Registration Number
NCT01312714
Locations
🇩🇰

Departments of Medical Research and Medicine, Holstebro Hospital, Holstebro, Denmark

Vitamin D Supplementation in Chronic Stable Heart Failure

First Posted Date
2011-02-09
Last Posted Date
2014-05-28
Lead Sponsor
Medical University of Graz
Target Recruit Count
29
Registration Number
NCT01292720
Locations
🇦🇹

Medical University of Graz, Graz, Austria

The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-01-17
Last Posted Date
2013-11-05
Lead Sponsor
Medical University of Warsaw
Target Recruit Count
60
Registration Number
NCT01277913
Locations
🇵🇱

Department of Pediatrics, Warsaw, Poland

Study of Vitamin D in Children With Sickle Cell Disease

Phase 1
Completed
Conditions
Interventions
First Posted Date
2011-01-13
Last Posted Date
2023-04-12
Lead Sponsor
Gary M Brittenham, MD
Target Recruit Count
4
Registration Number
NCT01276587
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

Paricalcitol Versus Calcitriol for the Management of Renocardiac Syndrome in Renal Transplant Patients

First Posted Date
2010-12-23
Last Posted Date
2015-06-09
Lead Sponsor
Ural State Medical University
Target Recruit Count
109
Registration Number
NCT01265615
Locations
🇷🇺

Ural Institute of Cardiology, Yekaterinburg, Russian Federation

🇳🇱

De Haar Research Foundation, Rotterdam, South Holland, Netherlands

Immune and Metabolic Effects of Vitamin D Supplementation in Healthy Humans

Phase 4
Completed
Conditions
Interventions
First Posted Date
2010-11-25
Last Posted Date
2012-02-09
Lead Sponsor
Medical University of Graz
Target Recruit Count
60
Registration Number
NCT01248442
Locations
🇦🇹

Medical University Graz, Graz, Austria

Study of the Effect of Vitamin D as an Add-on Therapy to Corticosteroids in Asthma

Phase 3
Completed
Conditions
Interventions
First Posted Date
2010-11-25
Last Posted Date
2014-08-13
Lead Sponsor
Milton S. Hershey Medical Center
Target Recruit Count
408
Registration Number
NCT01248065
Locations
🇺🇸

Emory University, Atlanta, Georgia, United States

🇺🇸

Rush University Medical Center/Stroger Hospital, Chicago, Illinois, United States

🇺🇸

University of Illinois at Chicago, Chicago, Illinois, United States

and more 13 locations

DAYLIGHT: Vitamin D Therapy in Individuals at High Risk of Hypertension

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2010-11-15
Last Posted Date
2017-03-09
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
534
Registration Number
NCT01240512
Locations
🇺🇸

Hartford Hospital, Hartford, Connecticut, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

Abbott Northwestern Hospital, Minneapolis, Minnesota, United States

Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome

First Posted Date
2010-11-10
Last Posted Date
2011-08-18
Lead Sponsor
University of Ioannina
Target Recruit Count
50
Registration Number
NCT01237769
Locations
🇬🇷

Outpatient Lipid Clinic, University Hospital of Ioannina, Ioannina, Greece

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