Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

Vitamin D and Arterial Function in Patients With Chronic Kidney Disease

First Posted Date
2011-06-29
Last Posted Date
2018-09-28
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
128
Registration Number
NCT01384539
Locations
🇺🇸

University of Colorado Denver Clinical Translational Research Center, Aurora, Colorado, United States

Vitamin D HIV Study on Postmenopausal Women

Phase 1
Completed
Conditions
Interventions
First Posted Date
2011-06-17
Last Posted Date
2019-03-07
Lead Sponsor
Columbia University
Target Recruit Count
85
Registration Number
NCT01375010
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

Vitamin D to Prevent Autism in Newborn Siblings

Phase 2
Completed
Conditions
Interventions
First Posted Date
2011-06-06
Last Posted Date
2016-06-14
Lead Sponsor
Oregon Health and Science University
Target Recruit Count
20
Registration Number
NCT01366885
Locations
🇺🇸

Evergreen Center, Oregon City, Oregon, United States

Effect of Vitamin D Repletion on Insulin Resistance and Systemic Inflammation

Phase 2
Completed
Conditions
Interventions
First Posted Date
2011-05-17
Last Posted Date
2020-11-02
Lead Sponsor
Albert Einstein College of Medicine
Target Recruit Count
19
Registration Number
NCT01354964
Locations
🇺🇸

Albert Einstein College of Medicine, Bronx, New York, United States

Effect of Vitamin D Replacement in Patients With Urolithiasis

Terminated
Conditions
Interventions
First Posted Date
2011-05-09
Last Posted Date
2016-05-05
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
10
Registration Number
NCT01349764
Locations
🇨🇦

Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec, Canada

Colecalciferol as an Add-on Treatment to Interferon-beta-1b for Treatment of Multiple Sclerosis (MS)

First Posted Date
2011-04-21
Last Posted Date
2011-05-19
Lead Sponsor
University of Turku
Target Recruit Count
70
Registration Number
NCT01339676
Locations
🇫🇮

Turku University Hospital, Turku, Finland

Vitamin D Deficiency and Atopic Dermatitis

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2011-04-19
Last Posted Date
2018-12-05
Lead Sponsor
Medical College of Wisconsin
Target Recruit Count
7
Registration Number
NCT01337635
Locations
🇺🇸

Children's Hospital of Wisconsin, Milwaukee, Wisconsin, United States

High Dose Vitamin D for Sickle Cell Disease

Phase 2
Completed
Conditions
Interventions
First Posted Date
2011-04-07
Last Posted Date
2022-08-09
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
46
Registration Number
NCT01331148
Locations
🇺🇸

Children's Healthcare of Atlanta, Atlanta, Georgia, United States

Vitamin D and Mortality in Heart Failure

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-03-31
Last Posted Date
2016-08-11
Lead Sponsor
Heart and Diabetes Center North-Rhine Westfalia
Target Recruit Count
400
Registration Number
NCT01326650
Locations
🇩🇪

Heart Center North Rhine-Westphalia, Bad Oeynhausen, Federal State of North Rhine-Westphalia, Germany

Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer

First Posted Date
2011-03-29
Last Posted Date
2016-08-03
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
15
Registration Number
NCT01325311
Locations
🇺🇸

Carolina Urologic Research Center, Myrtle Beach, South Carolina, United States

🇺🇸

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States

🇺🇸

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital, Baltimore, Maryland, United States

and more 8 locations
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