Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

Vitamin D and Grass Pollen Specific Immunotherapy

First Posted Date
2011-11-08
Last Posted Date
2015-06-25
Lead Sponsor
Charite University, Berlin, Germany
Target Recruit Count
35
Registration Number
NCT01466465
Locations
🇩🇪

Charité Universitätsmedizin Berlin, Allergy-Centre-Charité, CCM, Berlin, Germany

Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography

First Posted Date
2011-11-06
Last Posted Date
2011-11-22
Lead Sponsor
Isfahan University of Medical Sciences
Target Recruit Count
60
Registration Number
NCT01465893
Locations
🇮🇷

Isfahan Medical University, Tehran, Iran, Islamic Republic of

Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus

First Posted Date
2011-11-04
Last Posted Date
2016-03-10
Lead Sponsor
Case Comprehensive Cancer Center
Target Recruit Count
26
Registration Number
NCT01465113
Locations
🇺🇸

University Hospitals Ahuja Medical Center, Beachwood, Ohio, United States

🇺🇸

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

🇺🇸

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Vitamin and Asthma Study

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-10-06
Last Posted Date
2012-10-23
Lead Sponsor
Augusta University
Target Recruit Count
10
Registration Number
NCT01447173
Locations
🇺🇸

Pediatrics Allergy Clinic at Georgia Health Sciences University, Augusta, Georgia, United States

Vitamin D Levels in the Skin of Healthy Subjects After Oral Supplementation

First Posted Date
2011-10-06
Last Posted Date
2014-10-08
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
25
Registration Number
NCT01447355
Locations
🇺🇸

University of Arizona Health Sciences Center, Tucson, Arizona, United States

Colecalciferol as an Add-on Treatment to Subcutaneously-Administered Interferon-beta-1b for Treatment of Multiple Sclerosis (MS)

Phase 2
Completed
Conditions
Interventions
First Posted Date
2011-09-13
Last Posted Date
2011-09-13
Lead Sponsor
University of Turku
Target Recruit Count
70
Registration Number
NCT01432704

Changes in Breast Cancer Biomarkers Using Synergistic Prostaglandin Inhibitors

First Posted Date
2011-08-30
Last Posted Date
2017-08-09
Lead Sponsor
Hartford Hospital
Target Recruit Count
45
Registration Number
NCT01425476
Locations
🇺🇸

University of North Dakota, Grand Forks, North Dakota, United States

Study of Vitamin D Supplementation on Improvement of Gums Health

First Posted Date
2011-08-23
Last Posted Date
2017-04-20
Lead Sponsor
Aga Khan University
Target Recruit Count
115
Registration Number
NCT01422122
Locations
🇵🇰

AKU, Women & Child Health Outreach Office, Pind Dadan Khan, Punjab, Pakistan

Vitamin D and Physical Activity on Bone Health

First Posted Date
2011-08-18
Last Posted Date
2024-05-09
Lead Sponsor
University of Rochester
Target Recruit Count
191
Registration Number
NCT01419730
Locations
🇺🇸

University of Rochester, Rochester, New York, United States

Vitamin D and Its Affect on Growth Rates and Bone Mineral Density Until Age 5

First Posted Date
2011-08-18
Last Posted Date
2013-02-22
Lead Sponsor
Meir Medical Center
Target Recruit Count
200
Registration Number
NCT01419821
Locations
🇮🇱

Clalit Health services, Beitar Elit, Israel

© Copyright 2024. All Rights Reserved by MedPath