Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
- Conditions
- Interventions
- First Posted Date
- 2024-12-10
- Last Posted Date
- 2024-12-10
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT06725732
Effect of Tranexamic Acid and Calcium Dobesilate for Bleeding of Endometrial Origin
- First Posted Date
- 2024-11-27
- Last Posted Date
- 2024-11-27
- Lead Sponsor
- District Headquarters Teaching Hospital Sahiwal
- Target Recruit Count
- 100
- Registration Number
- NCT06707051
- Locations
- 🇵🇰
Sahiwal teaching Hospital Sahiwal, Sahiwal, Punjab, Pakistan
Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-10-26
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- Kristen Ban
- Target Recruit Count
- 394
- Registration Number
- NCT06657924
- Locations
- 🇺🇸
Cleveland Clinic Fairview Hospital, Cleveland, Ohio, United States
Window of Opportunity Study of Topical Tranexamic Acid for Cutaneous Squamous Cell Carcinoma
- Conditions
- Interventions
- First Posted Date
- 2024-10-16
- Last Posted Date
- 2024-10-16
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 32
- Registration Number
- NCT06644079
Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2024-10-11
- Last Posted Date
- 2024-10-11
- Lead Sponsor
- University of Kansas Medical Center
- Registration Number
- NCT06638749
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
Extended Oral Tranexamic Acid After Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2024-10-01
- Last Posted Date
- 2024-10-01
- Lead Sponsor
- Campbell Clinic
- Target Recruit Count
- 120
- Registration Number
- NCT06618820
- Locations
- 🇺🇸
Campbell Clinic, Germantown, Tennessee, United States
Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia
- Conditions
- Interventions
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2024-09-19
- Lead Sponsor
- University of Manitoba
- Target Recruit Count
- 75
- Registration Number
- NCT06599762
Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries
- Conditions
- Interventions
- First Posted Date
- 2024-09-09
- Last Posted Date
- 2024-09-09
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 78
- Registration Number
- NCT06587620
- Locations
- 🇪🇬
Faculty of medicine, zagazig university, Zagazig, Elsharqya, Egypt
🇪🇬Zagazig University, Zagazig, Egypt
Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
- First Posted Date
- 2024-06-28
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- Matthew Grosso, MD
- Target Recruit Count
- 80
- Registration Number
- NCT06479161
- Locations
- 🇺🇸
Trinity Health Of New England/CT Joint Replacement Institute, Hartford, Connecticut, United States
Comparison of Chitosan, Ankaferd and Tranexamic Acid in Dental Extraction in Liver Pre-Transplant Children
- Conditions
- Interventions
- First Posted Date
- 2024-06-13
- Last Posted Date
- 2024-10-18
- Lead Sponsor
- British University In Egypt
- Target Recruit Count
- 39
- Registration Number
- NCT06457360
- Locations
- 🇪🇬
British University in Egypt, Cairo, Egypt
Drug Development Updates
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