Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Tranexamic Acid's Effects in Patients Undergoing Laparoscopic Radical Prostatectomy
- First Posted Date
- 2023-04-18
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- Instituto do Cancer do Estado de São Paulo
- Target Recruit Count
- 122
- Registration Number
- NCT05816668
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women with Placenta Previa
- Conditions
- Interventions
- First Posted Date
- 2023-04-13
- Last Posted Date
- 2024-10-31
- Lead Sponsor
- Guangzhou Medical University
- Target Recruit Count
- 1680
- Registration Number
- NCT05811676
- Locations
- 🇨🇳
Huadu District People's Hospital of Guangzhou, Guangzhou, China
🇨🇳The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
🇨🇳The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Impact of Topical Tranexamic Acid in Breast Reconstruction
- First Posted Date
- 2023-04-10
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 23
- Registration Number
- NCT05807074
- Locations
- 🇺🇸
University of California, San Francisco, San Francisco, California, United States
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
- First Posted Date
- 2023-03-20
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT05774717
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Tranexamic Acid (TXA) in Hip Arthroscopy
- Conditions
- Interventions
- First Posted Date
- 2023-02-02
- Last Posted Date
- 2023-02-02
- Lead Sponsor
- Northwestern University
- Registration Number
- NCT05710146
- Locations
- 🇺🇸
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Tranexamic Acid During Upper GI Endoscopic Resection Procedures
- Conditions
- Interventions
- First Posted Date
- 2023-01-18
- Last Posted Date
- 2023-08-09
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 200
- Registration Number
- NCT05688020
- Locations
- 🇮🇱
Shamir Medical Center, Be'er Ya'aqov, Israel
The Role of Local Tranexamic Acid on Periorbital Oculoplastic Surgery
- Conditions
- Interventions
- First Posted Date
- 2023-01-05
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- University of Miami
- Registration Number
- NCT05672407
Anti-fibrinolytic and Anti-inflammatory Effects of Local Infiltration of Tranexamic Acid in Patients With Calcaneal Fractures
- Conditions
- Interventions
- First Posted Date
- 2022-10-28
- Last Posted Date
- 2022-10-28
- Lead Sponsor
- Hebei Medical University Third Hospital
- Target Recruit Count
- 113
- Registration Number
- NCT05598086
- Locations
- 🇨🇳
Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China
Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women at Higher Risk
- First Posted Date
- 2022-10-03
- Last Posted Date
- 2024-04-25
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 30000
- Registration Number
- NCT05562609
- Locations
- 🇹🇿
Mbeya Regional Referral Hospital, Mbeya, Tanzania
Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage
- Conditions
- Interventions
- First Posted Date
- 2022-09-26
- Last Posted Date
- 2023-09-18
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 30
- Registration Number
- NCT05554211
- Locations
- 🇺🇸
AMITA Health Saint Joseph Chicago, Chicago, Illinois, United States
🇺🇸Northwestern Memorial Hospital, Chicago, Illinois, United States
Drug Development Updates
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