Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.
- Conditions
- Interventions
- First Posted Date
- 2022-08-26
- Last Posted Date
- 2024-05-24
- Lead Sponsor
- Acibadem University
- Target Recruit Count
- 102
- Registration Number
- NCT05517590
- Locations
- 🇹🇷
Acibadem Maslak Hospital, Istanbul, Sariyer, Turkey
Tranexamic Acid During Excisional Burn Surgery
- Conditions
- Interventions
- First Posted Date
- 2022-08-19
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- Maasstad Hospital
- Target Recruit Count
- 96
- Registration Number
- NCT05507983
- Locations
- 🇳🇱
Maasstad Hospital, Rotterdam, Zuid-Holland, Netherlands
🇳🇱Red Cross Hospital, Beverwijk, Noord-Holland, Netherlands
🇳🇱Martini Hospital, Groningen, Netherlands
Alteration of Thrombelastography and Coagulation Function in Patients Undergoing Total Knee Arthroplasty With Intra-articular Tranexamic Acid Administration
- Conditions
- Interventions
- First Posted Date
- 2022-08-05
- Last Posted Date
- 2022-08-05
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 54
- Registration Number
- NCT05490160
Clinical Trial to Assess the Efficacy of Tranexamic Acid in Reducing Blood Loss in Hip Fracture Patients.
- Conditions
- Interventions
- First Posted Date
- 2022-08-05
- Last Posted Date
- 2023-05-17
- Lead Sponsor
- Biogipuzkoa Health Research Institute
- Target Recruit Count
- 644
- Registration Number
- NCT05489185
- Locations
- 🇪🇸
Asociación Instituto Biodonostia, San Sebastián, Guipuzcoa, Spain
Use of Tranexamic Acid After Vaginal Delivery with Episiotomy a RCT Placebo Control Trail
- Conditions
- Interventions
- First Posted Date
- 2022-07-07
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Assuta Ashdod Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT05448456
- Locations
- 🇮🇱
Assuta ashdod, Ashdod, Shfela, Israel
TXA Soaked Gelatin Sponge to Reduce Rectus Sheath Hematoma After C.S. in Patients Using Warfarin
- First Posted Date
- 2022-06-30
- Last Posted Date
- 2023-02-21
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 63
- Registration Number
- NCT05439694
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Tranexamic Acid in Proximal Humeral Fractures
- First Posted Date
- 2022-06-29
- Last Posted Date
- 2022-07-05
- Lead Sponsor
- Elda University Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT05437822
- Locations
- 🇪🇸
Elda University Hospital, Elda, Alicante, Spain
Prophylactic Tranexamic Acid Use After Vaginal Delivery
- Conditions
- Interventions
- First Posted Date
- 2022-06-23
- Last Posted Date
- 2023-12-04
- Target Recruit Count
- 480
- Registration Number
- NCT05429580
- Locations
- 🇹🇷
Nefise Nazlı YENIGUL, Bursa, Turkey
Prevention of Postpartum Hemorrhage With Tranexamic Acid (Phase 2)
- First Posted Date
- 2022-05-12
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- George Washington University
- Target Recruit Count
- 120
- Registration Number
- NCT05370820
- Locations
- 🇺🇸
George Washington University Hospital, Washington, District of Columbia, United States
🇺🇸Inova Health System, Falls Church, Virginia, United States
The Effect of Tranexamic Acid in Total Blood Loss During Proximal Femoral Nailing
- Conditions
- Interventions
- First Posted Date
- 2022-05-03
- Last Posted Date
- 2022-10-10
- Lead Sponsor
- Haseki Training and Research Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT05359172
- Locations
- 🇹🇷
Haseki TRH, Istanbul, Sultangazi, Turkey
Drug Development Updates
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