Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Use of Tranexamic Acid in Reduction Mammoplasty
- Conditions
- Interventions
- First Posted Date
- 2021-07-01
- Last Posted Date
- 2023-04-10
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 98
- Registration Number
- NCT04947514
- Locations
- 🇺🇸
Montefiore Medical Center Hutchinson Metro Center Campus, Bronx, New York, United States
Topical Tranexamic Acid for Bilateral Breast Reduction Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-06-09
- Last Posted Date
- 2022-04-06
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 106
- Registration Number
- NCT04918576
- Locations
- 🇨🇦
St. Joseph's Healthcare, King Campus, Hamilton, Ontario, Canada
🇨🇦Juravinski Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada
🇨🇦St. Joseph's Healthcare, Charlton Campus, Hamilton, Ontario, Canada
Tranexamic Acid for Alloplastic Breast Reconstruction
- Conditions
- Interventions
- First Posted Date
- 2021-06-09
- Last Posted Date
- 2022-04-06
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 106
- Registration Number
- NCT04918589
- Locations
- 🇨🇦
St. Joseph's Healthcare, King Campus, Hamilton, Ontario, Canada
🇨🇦St. Joseph's Healthcare, Charlton Campus, Hamilton, Ontario, Canada
🇨🇦Juravinski Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada
Comparison of Three Tranexamic Acid Dose Regimens in Patients Undergoing Cardiac Valve Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-06-03
- Last Posted Date
- 2021-08-31
- Target Recruit Count
- 210
- Registration Number
- NCT04911413
- Locations
- 🇨🇳
Fuwai Hospital, National Center for Cardiovascular Diseases, Beijing, Beijing, China
Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis
- First Posted Date
- 2021-06-02
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 80
- Registration Number
- NCT04910464
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Egypt
The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-06-01
- Last Posted Date
- 2021-06-01
- Lead Sponsor
- Ruby Grewal
- Target Recruit Count
- 50
- Registration Number
- NCT04907812
- Locations
- 🇨🇦
Lawson Health Research Institute, London, Ontario, Canada
Nebulized Tranexamic Acid in Sinus Surgery
- First Posted Date
- 2021-05-28
- Last Posted Date
- 2024-05-17
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT04905901
- Locations
- 🇪🇬
Assuit, Assiut, Assuit, Egypt
TXA in the Reduction of Post-Op Hematoma and Seroma in Patients Undergoing Panniculectomy or Abdominoplasty
- Conditions
- Interventions
- First Posted Date
- 2021-05-26
- Last Posted Date
- 2023-04-25
- Lead Sponsor
- The Reading Hospital and Medical Center
- Target Recruit Count
- 9
- Registration Number
- NCT04902950
- Locations
- 🇺🇸
Reading Hospital, West Reading, Pennsylvania, United States
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-04-28
- Last Posted Date
- 2022-04-05
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Registration Number
- NCT04863339
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
- First Posted Date
- 2021-03-24
- Last Posted Date
- 2024-06-26
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 46
- Registration Number
- NCT04814433
- Locations
- 🇺🇸
NYU Langone Health, New York, New York, United States
Drug Development Updates
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