Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Impact of Topical Tranexamic Acid on Pre- and Post-operative Hemoglobin/Hematocrit
- Conditions
- Interventions
- First Posted Date
- 2022-05-02
- Last Posted Date
- 2023-05-18
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 98
- Registration Number
- NCT05357079
- Locations
- 🇺🇸
University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
Tranexamic Acid During Colonic Endoscopic Resection Procedures
- First Posted Date
- 2022-04-26
- Last Posted Date
- 2024-08-07
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 200
- Registration Number
- NCT05345613
- Locations
- 🇮🇱
Shamir Medical Center, Be'er Ya'aqov, Israel
Blood Loss During Cesarean Delivery in Placenta Previa Patients
- Conditions
- Interventions
- First Posted Date
- 2022-04-22
- Last Posted Date
- 2023-01-06
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 81
- Registration Number
- NCT05340205
- Locations
- 🇪🇬
Kasralainy Cairo University, Giza, Egypt
Topical Tranexamic Acid Application in Rhinoplasty
- Conditions
- Interventions
- First Posted Date
- 2022-04-13
- Last Posted Date
- 2022-04-13
- Lead Sponsor
- Baskent University
- Target Recruit Count
- 50
- Registration Number
- NCT05326139
- Locations
- 🇹🇷
Baskent University Faculty of Medicine, Cankaya, Ankata, Turkey
Tranexamic Acid in Traumatic Brain Injury
- First Posted Date
- 2022-04-12
- Last Posted Date
- 2023-12-28
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 120
- Registration Number
- NCT05323149
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Assuit, Egypt
Tranexamic Acid During Telescoping Nail Application In Osteogenesis Imperfecta
- First Posted Date
- 2022-04-11
- Last Posted Date
- 2023-12-14
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 20
- Registration Number
- NCT05321199
- Locations
- 🇪🇬
Assiut University Hospitals, Assiut, Egypt
Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)
- Conditions
- Interventions
- First Posted Date
- 2021-10-18
- Last Posted Date
- 2024-05-16
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 110
- Registration Number
- NCT05082142
- Locations
- 🇺🇸
Northwestern University, Chicago, Illinois, United States
Tranexamic Acid Dosing for Major Joint Replacement Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-10-12
- Last Posted Date
- 2023-10-26
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 21
- Registration Number
- NCT05075200
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
A Randomized Controlled Trial of Inhaled Tranexamic Acid for the Treatment of Pulmonary Hemorrhage in Cancer Patients
- Conditions
- Interventions
- First Posted Date
- 2021-09-23
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 60
- Registration Number
- NCT05053867
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Effect of Early Administration of TXA in Adult Hip Fractures
- First Posted Date
- 2021-09-16
- Last Posted Date
- 2021-09-16
- Lead Sponsor
- Ascension Health
- Target Recruit Count
- 170
- Registration Number
- NCT05047133
- Locations
- 🇺🇸
Ascension Genesys Hospital, Grand Blanc, Michigan, United States
Drug Development Updates
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