Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Effect of no Drainage Tube on Blood Loss and Recovery After High Tibial Osteotomy
- Conditions
- Interventions
- First Posted Date
- 2019-05-17
- Last Posted Date
- 2020-02-19
- Lead Sponsor
- Qilu Hospital of Shandong University
- Target Recruit Count
- 80
- Registration Number
- NCT03954860
- Locations
- 🇨🇳
Qilu hospital of Shandong University, Jinan, Shandong, China
DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
- First Posted Date
- 2019-05-17
- Last Posted Date
- 2023-12-08
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 3242
- Registration Number
- NCT03954314
- Locations
- 🇨🇦
Kelowna General Hospital, Kelowna, British Columbia, Canada
🇨🇦Hamilton Health Sciences - General Hospital, Hamilton, Ontario, Canada
🇨🇦St. Boniface Hospital, Winnipeg, Manitoba, Canada
The Effect of Tranexamic Acid on Blood Coagulation in Total Hip Arthroplasty Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-04-01
- Last Posted Date
- 2023-04-14
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 50
- Registration Number
- NCT03897621
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Intravenous Oxytocin Versus Tranexamic Acid in Reducing Blood Loss During Abdominal Myomectomy.
- First Posted Date
- 2019-03-27
- Last Posted Date
- 2020-04-28
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 150
- Registration Number
- NCT03892668
- Locations
- 🇪🇬
faculty of medicine Cairo university, Giza, Egypt
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2019-02-27
- Last Posted Date
- 2021-01-19
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 110
- Registration Number
- NCT03856164
- Locations
- 🇺🇸
Parkland Hospital, Dallas, Texas, United States
Evaluation of the Safety and Efficacy of the Second Dose of Tranexamic Acid
- First Posted Date
- 2019-02-20
- Last Posted Date
- 2021-02-11
- Lead Sponsor
- Hamad Medical Corporation
- Target Recruit Count
- 220
- Registration Number
- NCT03846973
- Locations
- 🇶🇦
Hamad General Hospital, Doha, Qatar
Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-02-12
- Last Posted Date
- 2019-02-12
- Lead Sponsor
- SHI Jia
- Target Recruit Count
- 360
- Registration Number
- NCT03838328
- Locations
- 🇨🇳
Chinese Academy of Medical Sciences， Fuwai Hospital, Beijing, China
The Effectiveness Of Intravenous TXA on Reducing Perioperative Blood Loss For Patients Undergoing PAO
- First Posted Date
- 2019-01-30
- Last Posted Date
- 2019-10-04
- Lead Sponsor
- Boston Children's Hospital
- Registration Number
- NCT03823417
- Locations
- 🇺🇸
Boston children hospital, Boston, Massachusetts, United States
The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women
- Conditions
- Interventions
- First Posted Date
- 2019-01-29
- Last Posted Date
- 2020-01-06
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 160
- Registration Number
- NCT03820206
- Locations
- 🇪🇬
Kasr Alainy medical school, Cairo, Egypt
A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia
- Conditions
- Interventions
- First Posted Date
- 2019-01-16
- Last Posted Date
- 2021-09-20
- Lead Sponsor
- Meghan McCormick
- Target Recruit Count
- 11
- Registration Number
- NCT03806556
- Locations
- 🇺🇸
UPMC Childrens Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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