Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-12-10
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Bayside Health
- Target Recruit Count
- 3300
- Registration Number
- NCT04192435
- Locations
- 🇦🇺
Alfred Hospital, Melbourne, Victoria, Australia
Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy
- Conditions
- Interventions
- First Posted Date
- 2019-12-05
- Last Posted Date
- 2020-04-21
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT04188184
- Locations
- 🇪🇬
Faculty of Medicine, Asyut, Egypt
🇪🇬Assiut university, Assiut, Egypt
Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma
- Conditions
- Interventions
- First Posted Date
- 2019-11-20
- Last Posted Date
- 2019-12-17
- Lead Sponsor
- Jinnah Postgraduate Medical Centre
- Target Recruit Count
- 30
- Registration Number
- NCT04170088
- Locations
- 🇵🇰
Jinnah potgraduate Medical Centre ( JINNAH HOPITAL), Karachi, Sindh, Pakistan
Von Willebrand Factor in Pregnancy (VIP) Study
- First Posted Date
- 2019-10-31
- Last Posted Date
- 2021-01-28
- Lead Sponsor
- Bloodworks
- Target Recruit Count
- 110
- Registration Number
- NCT04146376
- Locations
- 🇺🇸
University of Colorado, Aurora, Colorado, United States
🇺🇸Yale University, New Haven, Connecticut, United States
🇺🇸University of Miami, Miami, Florida, United States
Tranexamic Acid Versus Sublingual Misoprostol in Reducing Blood Loss During Elective CS in High Risk Cases
- Conditions
- Interventions
- First Posted Date
- 2019-10-07
- Last Posted Date
- 2020-01-31
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 345
- Registration Number
- NCT04117243
- Locations
- 🇪🇬
Faculty of Medicine, Cairo, Egypt
A Study to Evaluate the Safety, Tolerability and Efficacy of LB1148 for Subjects Undergoing Elective Bowel Resection
- First Posted Date
- 2019-09-24
- Last Posted Date
- 2020-12-04
- Lead Sponsor
- Ronald Hurst, MD, FACS
- Target Recruit Count
- 11
- Registration Number
- NCT04100447
- Locations
- 🇺🇸
Centinela Hospital Medical Center, Inglewood, California, United States
Oral Versus Intravenous Tranexamic Acid
- First Posted Date
- 2019-09-13
- Last Posted Date
- 2023-09-29
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 400
- Registration Number
- NCT04089865
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Intranasal TXA for Anterior Epistaxis in the Emergency Department
- First Posted Date
- 2019-08-13
- Last Posted Date
- 2020-09-11
- Lead Sponsor
- Mercy Health Ohio
- Target Recruit Count
- 86
- Registration Number
- NCT04054687
- Locations
- 🇺🇸
St Elizabeth Boardman Hospital, Boardman, Ohio, United States
🇺🇸St Elizabeth Youngstown, Youngstown, Ohio, United States
Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial
- First Posted Date
- 2019-05-29
- Last Posted Date
- 2019-05-29
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 120
- Registration Number
- NCT03965767
- Locations
- 🇪🇬
Faculty of Medicine Ain Shams University, Cairo, Egypt
A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating of Melasma.
- Conditions
- Interventions
- First Posted Date
- 2019-05-24
- Last Posted Date
- 2021-03-11
- Lead Sponsor
- xjpfW
- Target Recruit Count
- 30
- Registration Number
- NCT03963466
- Locations
- 🇨🇳
Dermatology Derpartment of Xijing Hospital, Xi'an, Shaanxi, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.