Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Intravenous vs. Topical Tranexamic Acid in Revision THA (VITALITY-X)
- Conditions
- Interventions
- First Posted Date
- 2016-10-19
- Last Posted Date
- 2016-10-19
- Lead Sponsor
- Mount Sinai Hospital, Canada
- Target Recruit Count
- 160
- Registration Number
- NCT02938962
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Tranexamic Acid for Preventing Postpartum Hemorrhage After Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2016-10-18
- Last Posted Date
- 2016-10-18
- Lead Sponsor
- Shanghai First Maternity and Infant Hospital
- Target Recruit Count
- 6700
- Registration Number
- NCT02936661
Topical Intranasal Tranexamic Acid for Epistaxis in the Emergency Department
- First Posted Date
- 2016-10-12
- Last Posted Date
- 2021-11-30
- Lead Sponsor
- University of California, Davis
- Target Recruit Count
- 35
- Registration Number
- NCT02930941
- Locations
- 🇺🇸
University of California, Davis Medical Center, Sacramento, California, United States
Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA
- First Posted Date
- 2016-10-04
- Last Posted Date
- 2020-12-11
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 16
- Registration Number
- NCT02922582
- Locations
- 🇺🇸
Ortho Arizona, Gilbert, Arizona, United States
🇺🇸University of Miami Hospital, Miami, Florida, United States
🇺🇸Ohio State University/Wexner Medical Center, Columbus, Ohio, United States
The Effect of Topical Tranexamic Acid on Postoperative Bleeding From Superficial Wounds
- Conditions
- Interventions
- First Posted Date
- 2016-09-28
- Last Posted Date
- 2023-11-28
- Lead Sponsor
- St. Olavs Hospital
- Target Recruit Count
- 36
- Registration Number
- NCT02918201
- Locations
- 🇳🇴
St Olavs Hospital, Kirurgisk klinikk, Trondheim, Norway
🇳🇴Haukeland University Hospital, Burn Unit & Dept of Plastic Surgery, Bergen, Norway
IV Tranexamic Acid Prior to Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2016-09-22
- Last Posted Date
- 2022-08-09
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 71
- Registration Number
- NCT02911831
- Locations
- 🇺🇸
Northwestern University - Northwestern Medicine, Lavin Family Pavillion, Chicago, Illinois, United States
Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures
- First Posted Date
- 2016-09-21
- Last Posted Date
- 2019-07-29
- Lead Sponsor
- Yale University
- Target Recruit Count
- 6
- Registration Number
- NCT02908516
- Locations
- 🇺🇸
Yale New Haven Hospital, New Haven, Connecticut, United States
Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist
- Conditions
- Interventions
- First Posted Date
- 2016-08-15
- Last Posted Date
- 2022-04-04
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 64
- Registration Number
- NCT02866838
- Locations
- 🇨🇭
Stroke Center, University Hospital Basel, Basel, Switzerland
Tranexamic Acid and Blood Clots in Knee Surgery
- First Posted Date
- 2016-08-15
- Last Posted Date
- 2019-05-20
- Lead Sponsor
- University of New Mexico
- Target Recruit Count
- 25
- Registration Number
- NCT02867163
- Locations
- 🇺🇸
Sandoval Regional Medical Center, Rio Rancho, New Mexico, United States
Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study
- Conditions
- Interventions
- First Posted Date
- 2016-07-21
- Last Posted Date
- 2021-09-05
- Lead Sponsor
- Daniel Nishijima, MD, MAS
- Target Recruit Count
- 31
- Registration Number
- NCT02840097
- Locations
- 🇺🇸
University of California, Davis, Sacramento, California, United States
🇺🇸Nationwide Children's Hospital, Columbus, Ohio, United States
🇺🇸Primary Children's Hospital, Salt Lake City, Utah, United States
Drug Development Updates
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