Cefuroxime

Generic Name: Cefuroxime

Brand Names: Ceftin

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₆N_₄O_₈S

CAS Number: 55268-75-2

Unique Ingredient Identifier: O1R9FJ93ED

Background: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.

Indication: For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.

Associated Conditions: Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Animal bite, Bacterial Infections, Bone and Joint Infections, Impetigo, Lower Respiratory Tract Infection (LRTI), Lyme Disease, Maxillary Sinusitis, Meningitis, Neisseria Gonorrhoeae Infection, Septicemia, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Bacterial otitis media, Mild Streptococcal pharyngitis, Mild Streptococcal tonsillitis, Moderate Streptococcal pharyngitis, Moderate Streptococcal tonsillitis

Clinical Trials

Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients.

Recruiting

Conditions: Infection, Bacterial
Critically Ill
Sepsis
Septic Shock

Interventions: Drug: Cefuroxime
Drug: Amikacin

First Posted Date: 2020-07-14

Last Posted Date: 2022-09-10

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 40

Registration Number: NCT04470973

Locations: 🇳🇱
Radboudumc intensive care, Nijmegen, Netherlands

Role of Delay and Antibiotics on Perforation Rate While Waiting Appendectomy

Phase 4

Completed

Conditions: Appendicitis

Interventions: Drug: Antibiotics, cefuroxime and metronidazole
Drug: No antibiotics
Other: urgent schedule
Other: less urgent schedule

First Posted Date: 2020-05-07

Last Posted Date: 2023-07-11

Lead Sponsor: Helsinki University Central Hospital

Target Recruit Count: 1800

Registration Number: NCT04378868

Locations: 🇫🇮
HUS, Meilahti Hospital, Helsinki, Finland
🇫🇮
HUS, Jorvi Hospital, Espoo, Finland

24 Vs 48 Hours of Cefazolin or Cefuroxime as Prophylaxis

Phase 4

Completed

Conditions: Surgical Site Infection

Interventions: Drug: Cefuroxime
Drug: Cefazolin
Other: 48 hours
Other: 24 hours

First Posted Date: 2020-03-11

Last Posted Date: 2023-04-11

Lead Sponsor: Saud Al Babtain Cardiac Center

Target Recruit Count: 568

Registration Number: NCT04303390

Locations: 🇸🇦
Saud AlBabtain Cardiac Center, Dammam, Eastern Province, Saudi Arabia

Intracameral Levofloxacin (0.5%) vs Intracameral Cefuroxime

Phase 1

Conditions: Endophthalmitis Postoperative

Interventions: Drug: Levofloxacin Ophthalmic
Drug: Cefuroxime

First Posted Date: 2019-12-26

Last Posted Date: 2020-09-21

Lead Sponsor: National University of Malaysia

Target Recruit Count: 138

Registration Number: NCT04212078

Locations: 🇲🇾
UKM Medical Centre, Kuala Lumpur, Wilayah Persekutuan, Malaysia

Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial.

Phase 4

Conditions: Wounds and Injuries
Surgery--Complications

Interventions: Drug: Cefuroxime (750mg) I.V
Procedure: Colonic Surgery
Drug: Cefuroxime 750mg oral
Drug: Metronidazole 250 MG Oral Tablet [Flagyl]
Drug: Metronidazole 1 g Intravenous
Drug: Cefuroxime 1,5 g Intravenous
Drug: Sodium picosulfate, light magnesium oxide, anhydrous citric acid 10 mg/3.5 g/10.97 g Oral

First Posted Date: 2019-11-13

Last Posted Date: 2022-04-26

Lead Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Target Recruit Count: 968

Registration Number: NCT04161599

Locations: 🇬🇷
General University Hospital of Patras, Patra, Greece
🇪🇸
Hospital Universitario Lucus Augusti, Lugo, Spain
🇪🇸
Hospital General Universitario Vall d´Hebron, Barcelona, Barcelona, Spain, Spain

and more 7 locations