Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery

Phase 3

Recruiting

Conditions: Anesthesia

Interventions: Drug: Cipepofol
Drug: Propofol

First Posted Date: 2024-04-30

Last Posted Date: 2024-06-10

Lead Sponsor: Haisco Pharmaceutical Group Co., Ltd.

Target Recruit Count: 186

Registration Number: NCT06391931

Locations: 🇨🇳
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions

Phase 4

Not yet recruiting

Conditions: Hemodynamics Instability
Amobarbital Sodium

Interventions: Drug: Amobarbital
Drug: Propofol

First Posted Date: 2024-04-26

Last Posted Date: 2024-05-22

Lead Sponsor: Tongji Hospital

Target Recruit Count: 96

Registration Number: NCT06385756

Comparison of Remimazolam and Propofol Combination vs. Propofol in IOM

Phase 4

Not yet recruiting

Conditions: Neurologic Disorder

Interventions: Drug: Remimazolam besylate + propofol MCT
Drug: Propofol MCT

First Posted Date: 2024-04-24

Last Posted Date: 2024-04-24

Lead Sponsor: Chung-Ang University Gwangmyeong Hospital

Target Recruit Count: 56

Registration Number: NCT06382467

Intermittent Boluses Versus Infusion of Propofol During Gastroscopy

Not Applicable

Not yet recruiting

Conditions: Anesthesia

Interventions: Drug: Propofol 100 MG in 10 ML Injection

First Posted Date: 2024-04-23

Last Posted Date: 2024-08-07

Lead Sponsor: Al-Balqa Applied University

Target Recruit Count: 100

Registration Number: NCT06378879

The Sedative Effects of Dexmedetomidine VS Propofol During Peribulbar Anesthesia in Patients Undergoing Vitrectomy Surgery

Phase 4

Recruiting

Conditions: Patient
Satisfaction

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2024-04-16

Last Posted Date: 2024-04-16

Lead Sponsor: Beni-Suef University

Target Recruit Count: 420

Registration Number: NCT06369103

Locations: 🇪🇬
Beni Suef University Hospital, Banī Suwayf, Beni Suef, Egypt

Comparison of Remimazolam and Propofol Effect on Oxygen Reserve During Endoscopic Retrograde Cholangiopancreatography

Not Applicable

Recruiting

Conditions: Hepatobiiliary Diseases Requiring Endoscopic Retrograde Cholangiopancreatography

Interventions: Drug: Remimazolam besylate
Drug: Propofol

First Posted Date: 2024-04-11

Last Posted Date: 2024-04-11

Lead Sponsor: Yonsei University

Target Recruit Count: 112

Registration Number: NCT06359834

Locations: 🇰🇷
Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Republic of