Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Balanced Propofol Sedation Versus Propofol Alone Sedation in Therapeutic Endoscopic Retrograde Cholangiopancreatography (ERCP)

Phase 4

Conditions: Conscious Sedation Failure During Procedure

Interventions: Drug: Propofol
Drug: BPS

First Posted Date: 2011-03-23

Last Posted Date: 2011-03-23

Lead Sponsor: Soon Chun Hyang University

Target Recruit Count: 204

Registration Number: NCT01321047

A Study to Assess the Transfer of Fospropofol and Its Active Metabolite, Propofol, to Breast Milk Following Administration of LUSEDRA to Lactating Women Undergoing a Needed Procedure

Phase 1

Completed

Conditions: Lactating Women

Interventions: Drug: Lusedra
Drug: Propofol

First Posted Date: 2011-03-07

Last Posted Date: 2015-11-03

Lead Sponsor: Eisai Inc.

Target Recruit Count: 10

Registration Number: NCT01309984

Locations: 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States

The Use of Ketamine as an Anaesthetic During Electroconvulsive Therapy

Phase 4

Completed

Conditions: Depression

Interventions: Drug: Propofol
Drug: Ketamine

First Posted Date: 2011-03-02

Last Posted Date: 2016-09-08

Lead Sponsor: University of Aberdeen

Target Recruit Count: 40

Registration Number: NCT01306760

Locations: 🇬🇧
Royal Cornhill Hospital, NHS Grampian, Aberdeen, United Kingdom

Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery

Phase 3

Completed

Conditions: Coronary Artery Disease
General Anesthetic Drug Allergy
Coronary Artery Bypass Graft Surgery

Interventions: Drug: Sevoflurane
Drug: Propofol
Drug: Xenon

First Posted Date: 2011-02-11

Last Posted Date: 2015-12-21

Lead Sponsor: Air Liquide Santé International

Target Recruit Count: 509

Registration Number: NCT01294163

Locations: 🇳🇱
Thorax Center - Erasmus MC, Rotterdam, Netherlands
🇩🇪
University Hospital Aachen, Aachen, Germany
🇫🇷
Hôpital Pontchaillou, Rennes, France

and more 14 locations