Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel. Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and promote to cell death. Compared to paclitaxel, docetaxel is two times more potent as an inhibitor of microtubule depolymerization. Docetaxel binds to microtubules but does not interact with dimeric tubulin.
The use of docetaxel may lead to udesired outcomes such as hepatic impairment, hematologic effects, enterocolitis and neutropenic colitis, hypersensitivity reactions, fluid retention, second primary malignancies, embryo-fetal toxicity, and tumor lysis syndrome. Docetaxel was approved by the FDA in 1996 and is available in solution for injection for intravenous or parenteral administration.
Docetaxel is indicated as a single agent for the treatment of locally advanced or metastatic breast cancer after chemotherapy failure; and with doxorubicin and cyclophosphamide as adjuvant treatment of operable node-positive BC. It is also indicated as a single agent for locally advanced or metastatic non-small cell lung cancer (NSCLC) after platinum therapy failure; and with cisplatin for unresectable, locally advanced or metastatic untreated NSCLC. For the treatment of metastatic castration-resistant prostate cancer, docetaxel is indicated with prednisone. Docetaxel is also indicated with cisplatin and fluorouracil for untreated, advanced gastric adenocarcinoma, including the gastroesophageal junction, and with cisplatin and fluorouracil for induction treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN).
C.H. Senlis, Senlis, France
Hopital Saint Antoine, Paris, France
Intercommunal Hospital, Montfermeil, France
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
St. Thomas Health Services, Nashville, Tennessee, United States
CCOP - Duluth, Duluth, Minnesota, United States
Siouxland Hematology-Oncology, Sioux City, Iowa, United States
CentraCare Clinic, Saint Cloud, Minnesota, United States
Silver Cross Hospital, Joliet, Illinois, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, United States
Evanston Northwestern Health Care - Evanston Hospital, Evanston, Illinois, United States
Princess Margaret Hospital Phase 2 Consortium, Toronto, Ontario, Canada
Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Ireland Cancer Center, Cleveland, Ohio, United States
C.R.C. Beatson Laboratories, Glasgow, Scotland, United Kingdom
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
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