Vinblastine

Generic Name
Vinblastine
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C46H58N4O9
CAS Number
865-21-4
Unique Ingredient Identifier
5V9KLZ54CY
Background

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

Indication

For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Associated Conditions
Advanced Soft Tissue Sarcoma, Autoimmune Hemolytic Anemia, Bladder Cancer, Hodgkin's Lymphoma, Immune Thrombocytopenia (ITP), Kaposi's Sarcoma, Letterer-Siwe disease, Metastatic Melanoma, Non-Small Cell Lung Cancer (NSCLC), Advanced Alibert-Bazin syndrome, Advanced Testicular cancer, Histiocytic lymphoma, Refractory Breast cancer
Associated Therapies
-

First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia (HL-Russia-1)

First Posted Date
2020-11-20
Last Posted Date
2022-11-01
Lead Sponsor
State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Target Recruit Count
300
Registration Number
NCT04638790
Locations
🇮🇳

Tata Memorial Hospital, Mumbai, OPD-81 Main building, Dr. E Borges Road, Parel 400012, India

🇷🇺

The Federal Budget-Funded Institution National Medical Surgical Center named after N. I. Pirogov of the Ministry of health of the Russian Federation, Moscow, Russian Federation

Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

First Posted Date
2018-11-28
Last Posted Date
2024-04-04
Lead Sponsor
St. Jude Children's Research Hospital
Target Recruit Count
250
Registration Number
NCT03755804
Locations
🇺🇸

Maine Children's Cancer Program, Scarborough, Maine, United States

🇺🇸

St. Jude Affiliate Baton Rouge Clinic (Our Lady of the Lakes Regional Medical Center), Baton Rouge, Louisiana, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

and more 5 locations

Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

First Posted Date
2018-08-24
Last Posted Date
2024-11-05
Lead Sponsor
Seagen Inc.
Target Recruit Count
255
Registration Number
NCT03646123
Locations
🇺🇸

Texas Oncology - Flower Mound, Flower Mound, Texas, United States

🇺🇸

Clinical Research Alliance - Abraham Mittelman, MD, LLC, Purchase, New York, United States

🇨🇿

Fakultni Nemocnice Kralovske Vinohrady, Praha 10, Other, Czechia

and more 73 locations

Nivolumab in Combination With Metronomic Chemotherapy in Paediatrics Refractory / Relapsing Solid Tumors

First Posted Date
2018-07-13
Last Posted Date
2024-05-06
Lead Sponsor
Centre Oscar Lambret
Target Recruit Count
63
Registration Number
NCT03585465
Locations
🇧🇪

University Hospital Ghent, Gent, Belgium

🇧🇪

University Hospital Leuven, Leuven, Belgium

🇫🇷

Centre Oscar Lambret, Lille, France

and more 8 locations

Study Of Nivolumab Alone, Or In Combination With Vinblastin In Patients With Classical Hodgkin Lymphoma

First Posted Date
2018-07-09
Last Posted Date
2022-08-19
Lead Sponsor
The Lymphoma Academic Research Organisation
Target Recruit Count
64
Registration Number
NCT03580408
Locations
🇫🇷

CHU de Clermont Ferrand, Clermont Ferrand, France

🇫🇷

CHU de Dijon - Hôpital le Bocage, Dijon, France

🇧🇪

Clinique Universitaire Saint LUC, Brussels, Belgium

and more 48 locations

OPTmizing Advanced Stage HodgkIn LymphoMa patIentS Therapy

First Posted Date
2018-05-17
Last Posted Date
2019-11-18
Lead Sponsor
King Abdullah International Medical Research Center
Target Recruit Count
220
Registration Number
NCT03527628
Locations
🇸🇦

King Abdulaziz Medical City, Ministry of National Guard, Riyadh, Saudi Arabia

Very Early PET-response Adapted Targeted Therapy for Advanced Hodgkin Lymphoma: a Single -Arm Phase II Study

First Posted Date
2018-05-07
Last Posted Date
2023-11-09
Lead Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Target Recruit Count
150
Registration Number
NCT03517137
Locations
🇳🇱

Amsterdam UMC - Locatie AMC, Amsterdam, Netherlands

🇳🇱

Erasmus MC, Rotterdam, Netherlands

🇵🇱

Maria Sklodowska Curie National Institute of Oncology - National Research Institute, Warsaw, Poland

and more 13 locations

Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)

First Posted Date
2018-01-23
Last Posted Date
2024-11-20
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
340
Registration Number
NCT03407144
Locations
🇺🇸

University of Chicago ( Site 0066), Chicago, Illinois, United States

🇺🇸

Cohen Children's Medical Center of New York ( Site 0052), New Hyde Park, New York, United States

🇺🇸

Columbia University/Herbert Irving Cancer Center ( Site 0063), New York, New York, United States

and more 90 locations
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