Trimetazidine

Generic Name: Trimetazidine

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₂₂N_₂O_₃

CAS Number: 5011-34-7

Unique Ingredient Identifier: N9A0A0R9S8

Background: Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. Trimetazidine has been studied as a treatment for angina pectoris since the late 1960s.

Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response to myocardial ischemia, activate sodium-hydrogen and sodium-calcium antiport systems. The increased intracellular calcium decreases contractility. It is hypothesized that trimetazidine inhibits 3-ketoacyl coenzyme A thiolase, which decreases fatty acid oxidation but not glucose metabolism, preventing the acidic conditions that exacerbate ischemic injury. However, evidence for this mechanism is controversial.

Trimetazidine is not FDA approved. However, it has been approved in France since 1978.

Indication: Trimetazidine is indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies.

Associated Conditions: Angina Pectoris, Chronic Stable Angina Pectoris, Tinnitus, Vertigo, Decreased visual acuity caused by Vascular Disorders

Clinical Trials

Trimetazidine As a Potential Adjuvant Therapy in Acute Aluminum Phosphide Poisoning-induced Cardiotoxicity

Not Applicable

Conditions: Aluminum Phosphide Poisoning

Interventions: Other: standard treatment
Drug: trimetazidine hydrochloride "metacardia" ® 20 mg tablet

First Posted Date: 2021-01-11

Last Posted Date: 2021-01-11

Lead Sponsor: Tanta University

Target Recruit Count: 40

Registration Number: NCT04702906

Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris

Phase 4

Conditions: Coronary Heart Disease
Unstable Angina
Chinese Herbal Medicine

Interventions: Drug: Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet
Drug: Wen Xin granule
Drug: Atorvastatin Calcium
Drug: Isosorbide Mononitrate Tab 20 MG
Drug: Metoprolol Tartrate Tab 25 MG
Drug: Aspirin Enteric-coated Tablets
Drug: WXG placebo
Drug: Trimetazidine Dihydrochloride Tablets
Drug: glyceryl trinitrate

First Posted Date: 2020-12-10

Last Posted Date: 2021-01-25

Lead Sponsor: Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Target Recruit Count: 502

Registration Number: NCT04661709

Efficacy of Personalized Exercise Program and Trimetazidine in Rehabilitation of Patients After RFA of AF

Not Applicable

Completed

Conditions: Atrial Fibrillation Paroxysmal

Interventions: Other: Physical training program
Drug: Trimetazidine

First Posted Date: 2020-08-13

Last Posted Date: 2021-06-09

Lead Sponsor: National Research Center for Preventive Medicine

Target Recruit Count: 72

Registration Number: NCT04511520

Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart Disease

Phase 4

Conditions: Coronary Heart Disease
Diastolic Dysfunction

Interventions: Drug: Trimetazidine

First Posted Date: 2019-03-22

Last Posted Date: 2019-03-25

Lead Sponsor: China National Center for Cardiovascular Diseases

Target Recruit Count: 226

Registration Number: NCT03887013

Locations: 🇨🇳
Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing, Beijing, China

Effects of Yangxinshi Pills on the Exercise Tolerance Compared With Trimetazidine in Patients After PCI

Phase 4

Conditions: Percutaneous Coronary Intervention

Interventions: Drug: Yangxinshi
Drug: Trimetazidine
Drug: Trimetazidine mimic
Drug: Yangxinshi mimic

First Posted Date: 2019-01-18

Last Posted Date: 2020-10-19

Lead Sponsor: Shenyang Northern Hospital

Target Recruit Count: 668

Registration Number: NCT03809273

Locations: 🇨🇳
Beijing Anzhen Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China
🇨🇳
Hebei General Hospital, Shijiazhuang, Hebei, China

and more 12 locations