Povidone-iodine

Generic Name: Povidone-iodine

Brand Names: Betadine, Kenalog, Marbeta, Marcaine, P-Care M, P-Care MG, P-care, P-care X, Summer's Eve Medicated

Drug Type: Small Molecule

CAS Number: 25655-41-8

Unique Ingredient Identifier: 85H0HZU99M

Background: Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. During in vitro testing to demonstrate anti-bacterial activity it was found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.

Indication: For topical application in the treatment and prevention of infection in wounds.

Associated Conditions: Skin Infections

Associated Therapies: Skin disinfection, Antiseptic skin preparation therapy, Irrigation of the ocular surface therapy, Prepping of the periocular region

Clinical Trials

Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis

Phase 4

Withdrawn

Conditions: Lumbar Spinal Stenosis

Interventions: Drug: Kenalog Injectable Product
Drug: Decadron Phosphate, Injectable
Procedure: Epidural Steroid Injection

First Posted Date: 2017-08-10

Last Posted Date: 2017-12-06

Lead Sponsor: Hospital for Special Surgery, New York

Registration Number: NCT03245671

Locations: 🇺🇸
Hospital for Special Surgery, New York, New York, United States

A Trial to Evaluate the Efficacy and Safety of Two Concentrations of VBP-926 Solution for the Treatment of Chemotherapy-associated Paronychia in Cancer Patients

Phase 2

Completed

Conditions: Chemotherapy-Associated Paronychia

Interventions: Drug: VBP-926

First Posted Date: 2017-07-05

Last Posted Date: 2019-01-25

Lead Sponsor: Veloce BioPharma LLC

Target Recruit Count: 102

Registration Number: NCT03207906

Locations: 🇺🇸
Compassionate Cancer Care, Fountain Valley, California, United States
🇺🇸
Ohio State University, Columbus, Ohio, United States
🇺🇸
Bryn Mawr Skin & Cancer Institute, Bryn Mawr, Pennsylvania, United States

and more 5 locations

S. Aureus Decolonization in HPN Patients.

Not Applicable

Terminated

Conditions: Motility Disorder
Staphylococcus Aureus

Interventions: Drug: Doxycycline
Drug: Trimethoprim
Drug: Sulfamethoxazole/trimethoprim
Drug: Clindamycin
Drug: Clarithromycin
Drug: Ciprofloxacin
Drug: Fusidic Acid
Drug: Rifampin
Drug: Chlorhexidine
Drug: Mupirocin
Drug: Betadine

First Posted Date: 2017-06-01

Last Posted Date: 2022-05-31

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 63

Registration Number: NCT03173053

Locations: 🇩🇰
Rigshospitalet, Copenhagen, Denmark
🇩🇰
Aalborg Universitetshospital, Aalborg, Denmark
🇳🇱
Radboud UMC, Nijmegen, Gelderland, Netherlands

and more 1 locations

Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery

Phase 4

Completed

Conditions: Infection, Bacterial

Interventions: Drug: Povidone-Iodine Scrub and Paint
Drug: Chlorhexidine Gluconate

First Posted Date: 2017-04-28

Last Posted Date: 2019-03-11

Lead Sponsor: Metro Health, Michigan

Target Recruit Count: 100

Registration Number: NCT03133312

Locations: 🇺🇸
Metro Health, Wyoming, Michigan, United States

Treatment of Bacterial Conjunctivitis With SHP640 Compared to PVP-Iodine and Placebo

Phase 3

Completed

Conditions: Bacterial Conjunctivitis

Interventions: Drug: PVP-I 0.6%
Drug: Placebo
Drug: SHP640

First Posted Date: 2016-12-29

Last Posted Date: 2021-06-09

Lead Sponsor: Shire

Target Recruit Count: 753

Registration Number: NCT03004924

Locations: 🇺🇸
Sok H. Nam, M.D. Inc., Los Angeles, California, United States
🇺🇸
Danbury Eye Physicians and Surgeons, Danbury, Connecticut, United States
🇪🇸
Instituto Oftalmológico Fernández-Vega, Oviedo, Asturias, Spain

and more 158 locations

Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo

Phase 3

Terminated

Conditions: Adenoviral Conjunctivitis

Interventions: Other: Placebo
Drug: SHP640
Drug: PVP-I 0.6%

First Posted Date: 2016-12-20

Last Posted Date: 2021-06-14

Lead Sponsor: Shire

Target Recruit Count: 219

Registration Number: NCT02998541

Locations: 🇺🇸
Mercy Research, Springfield, Missouri, United States
🇪🇸
Instituto Oftalmológico Fernández-Vega, Oviedo, Asturias, Spain
🇺🇸
Lakeside Vision Center, Irvine, California, United States

and more 126 locations

AvenovaTM as a Sterile Skin Preparation Agent

Early Phase 1

Completed

Conditions: Cleaning Product Causing Toxic Effect

Interventions: Device: Avenova
Drug: Povidone-iodine 5% solution
Drug: 4% chlorhexidine
Drug: Isopropyl alcohol

First Posted Date: 2016-12-12

Last Posted Date: 2020-02-05

Lead Sponsor: University of Miami

Target Recruit Count: 21

Registration Number: NCT02990013

Locations: 🇺🇸
University of Miami Bascom Palmer Eye Institute, Miami, Florida, United States

Betadine Pleurodesis Via Tunneled Pleural Catheters

Phase 4

Withdrawn

Conditions: Pleurodesis
Pleural Effusions, Chronic
Pleural Effusion
Malignant Pleural Effusion
Pleural Effusion Due to Congestive Heart Failure
Pleural Effusion in Conditions Classified Elsewhere