DeepMed Research

Calcipotriol

Generic Name: Calcipotriol

Brand Names: Calcitrene, Dovobet, Dovonex, Enstilar, Sorilux, Taclonex, Wynzora

Drug Type: Small Molecule

Chemical Formula: C_₂₇H_₄₀O_₃

CAS Number: 112965-21-6

Unique Ingredient Identifier: 143NQ3779B

Background: Calcipotriol (INN) or calcipotriene (USAN) is a sythetic derivative of calcitriol or Vitamin D.

Indication: For the treatment of moderate plaque psoriasis in adults.

Associated Conditions: Plaque psoriasis of the scalp, Psoriasis Vulgaris (Plaque Psoriasis)

Clinical Trials

Immunotherapy After Transplantation for Skin Cancer Prevention in Organ Transplant Recipients

Phase 2

Withdrawn

Conditions: Immunotherapy
Cutaneous Squamous Cell Carcinoma
Actinic Keratoses
Organ Transplant Recipients
Skin Cancer

Interventions: Drug: Calcipotriol Only Product in Cutaneous Dose Form
Drug: Vaseline
Drug: Topical 5FU

First Posted Date: 2020-11-24

Last Posted Date: 2025-05-07

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 64

Registration Number: NCT04642287

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Barnes-Jewish Hospital, Saint Louis, Missouri, United States

Assessing the Efficacy of Image-guided Laser-assisted Enstilar® Delivery for Treatment of Psoriatic Nails

Phase 2

Completed

Conditions: Nail Psoriasis

Interventions: Drug: Enstilar
Device: Ablative fractional laser

First Posted Date: 2020-10-08

Last Posted Date: 2022-03-02

Lead Sponsor: Bispebjerg Hospital

Target Recruit Count: 11

Registration Number: NCT04580537

Locations: 🇩🇰
Bispebjerg Hospital, Copenhagen, Capital Region, Denmark

Efficacy and Safety of Sorilux in Maintenance Treatment of Moderate Type Plaque Psoriasis

Phase 4

Conditions: Plaque Psoriasis

Interventions: Drug: LEXETTE 0.05% Topical Foam
Drug: Sorilux 0.005 % Topical Foam
Other: Vehicle Foam

First Posted Date: 2020-09-30

Last Posted Date: 2020-11-20

Lead Sponsor: Skin Sciences, PLLC

Target Recruit Count: 30

Registration Number: NCT04571151

Locations: 🇺🇸
Skin Sciences, PLLC, Louisville, Kentucky, United States

The Maintenance Effect of Enstilar Foam in Combination With Otezla

Phase 4

Conditions: Psoriasis

Interventions: Drug: Apremilast 30mg
Drug: calcipotriene and betamethasone dipropionate

First Posted Date: 2020-09-21

Last Posted Date: 2020-10-09

Lead Sponsor: Derm Research, PLLC

Target Recruit Count: 30

Registration Number: NCT04555707

Locations: 🇺🇸
Skin Sciences, PLLC, Louisville, Kentucky, United States

Observational Study in Patients With Nail Psoriasis Treated With Enstilar® to Assess the Severity Change and the Quality of Life

Completed

Conditions: Nail Psoriasis

Interventions: Drug: Calcipotriene and betamethasone dipropionate aerosol foam

First Posted Date: 2020-05-08

Last Posted Date: 2021-08-02

Lead Sponsor: Angeles Florez

Target Recruit Count: 10

Registration Number: NCT04380597

Locations: 🇪🇸
Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Spain

Taltz in Combination With Enstilar for Psoriasis

Phase 4

Recruiting

Conditions: Psoriasis

Interventions: Drug: Enstilar

First Posted Date: 2020-05-04

Last Posted Date: 2020-05-04

Lead Sponsor: Psoriasis Treatment Center of Central New Jersey

Target Recruit Count: 25

Registration Number: NCT04372277

Locations: 🇺🇸
Psoriasis Treatment Center of Central New Jersey, East Windsor, New Jersey, United States

Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients

Phase 2

Withdrawn

Conditions: Skin Cancer
Immunotherapy
Cutaneous Squamous Cell Carcinoma
Organ Transplant Recipients
Actinic Keratoses

Interventions: Drug: Calcipotriol Only Product in Cutaneous Dose Form
Drug: Vaseline
Drug: Topical 5FU

First Posted Date: 2020-04-01

Last Posted Date: 2025-05-07

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 62

Registration Number: NCT04329221

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Barnes-Jewish Hospital, Saint Louis, Missouri, United States

Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment and PSORI-CM01 Granule in Psoriasis Patients

Not Applicable

Completed

Conditions: Mesenchymal Stromal Cells
Drug Effect
Psoriasis
Drug Toxicity

Interventions: Drug: Calcipotriol ointment
Drug: PSORI-CM01 Granule
Biological: adipose-derived multipotent mesenchymal stem cells

First Posted Date: 2020-02-19

Last Posted Date: 2023-08-24

Lead Sponsor: Guangdong Provincial Hospital of Traditional Chinese Medicine

Target Recruit Count: 8

Registration Number: NCT04275024

Locations: 🇨🇳
Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong, China

A Study Evaluating the Efficacy and Tolerability of Enstilar Foam in Patients With Nail Psoriasis

Phase 4

Completed

Conditions: Nail Psoriasis

Interventions: Drug: Enstilar Foam

First Posted Date: 2020-01-13

Last Posted Date: 2025-01-17

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 6

Registration Number: NCT04227288

Locations: 🇺🇸
The University of Alabama at Birmingham, Birmingham, Alabama, United States

Combination Topical Therapy for Treatment of Scalp Actinic Keratoses

Early Phase 1

Terminated

Conditions: Actinic Keratoses

Interventions: Drug: Calcipotriene 0.005% Foam
Drug: Efudex 5% Topical Cream

First Posted Date: 2019-06-24

Last Posted Date: 2020-12-07

Lead Sponsor: Tulane University

Target Recruit Count: 15

Registration Number: NCT03996252

Locations: 🇺🇸
Tulane University Medical Center, New Orleans, Louisiana, United States

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