MedPath

Sodium fluoride

Generic Name
Sodium fluoride
Brand Names
60 Second Taste, Clinpro 5000, Ctx4 Gel, Denta 5000 Plus, Denticare Denti Foam, Denticare Neutral, Denticare Pro Gel, Fluorishield, Fluoritab, Flura-drops, Gelato Sodium Fluoride, Kolorz, Ludent, Meijer, Mvc-fluoride, Neutracare, Neutramaxx, Oral-B Minute-foam, Oral-B Neutra, Pcxx Neutral Foam, Pcxx Neutral Rinse, Perfect Choice One Minute, Prevident, Prevident 5000 Sensitive, Prevident Dental Rinse, Prodenrx Rinse, Zooby Fluoride Foam
Drug Type
Small Molecule
Chemical Formula
FNa
CAS Number
7681-49-4
Unique Ingredient Identifier
8ZYQ1474W7
Background

Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as Fluoride ion F-18. Sodium fluoride's benefits on dental health were first observed in the 1930s, when individuals in communities with fluoridated drinking water showed less tooth decay than those without fluoridated water. The use of fluoride in dental practice began in the 1940s. Now, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care. According to the American Dental Association (ADA), thorough evidence reviews have indicated that the use of fluoride to prevent and control dental caries is safe when used correctly and is highly effective in reducing the prevalence of caries.

Indication

Sodium fluoride in the oral or topical form is indicated for the prevention and control of dental caries and for the maintenance of dental health. Fluoride supplements in the form of tablets and other formulas may be prescribed to prevent tooth decay in high-risk children aged 6 months to 16 years old whose drinking water source contains low fluoride concentrations.

Associated Conditions
Cavity, Dental Cavity, Dental Decay, Dental Health, Enamel Caries, Partial Denture Wearers Wear of the Natural Enamel, Sensitivity, Tooth, Trace Element Deficiency, Wear of the Natural Enamel caused by teeth grinding
Associated Therapies
Parenteral Nutrition

The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish

Phase 1
Completed
Conditions
Early Childhood Caries
Interventions
First Posted Date
2024-03-18
Last Posted Date
2024-03-18
Lead Sponsor
Universiti Teknologi Mara
Target Recruit Count
49
Registration Number
NCT06316323
Locations
🇲🇾

University Technology MARA, Sungai Buloh, Selangor, Malaysia

Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101

Phase 1
Completed
Conditions
Caries,Dental
Interventions
First Posted Date
2023-12-26
Last Posted Date
2024-01-02
Lead Sponsor
Colgate Palmolive
Target Recruit Count
29
Registration Number
NCT06182267
Locations
🇺🇸

TKL Research, Inc, Fair Lawn, New Jersey, United States

The Effect of Sodium Fluoride Application on the Prevention of Radiation Caries in NPC Patients

Phase 2
Not yet recruiting
Conditions
Sodium Fluoride
Interventions
First Posted Date
2023-12-18
Last Posted Date
2023-12-18
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
135
Registration Number
NCT06174012

Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH

Phase 3
Completed
Conditions
Dentin Hypersensitivity
Interventions
Drug: Fluoro-Calcium-Phospho-Silicate based dentifrices
First Posted Date
2020-01-30
Last Posted Date
2021-05-11
Lead Sponsor
Dow University of Health Sciences
Target Recruit Count
140
Registration Number
NCT04249336
Locations
🇵🇰

Dr Syed Jaffar Abbas Zaidi, Karachi, Sindh, Pakistan

Remineralization Effect of Fluoride Varnishes on Permanent Molars

First Posted Date
2019-10-14
Last Posted Date
2019-10-15
Lead Sponsor
Kırıkkale University
Target Recruit Count
40
Registration Number
NCT04124887
Locations
🇹🇷

Kırıkkale University, Kırıkkale, Turkey

MI and PreviDent Varnish on Non Cavitated Interproximal Lesions.

Phase 4
Conditions
Prevention
Interventions
Drug: 1.23% APF
Drug: MI Varnish
First Posted Date
2019-04-24
Last Posted Date
2020-04-09
Lead Sponsor
King Abdulaziz University
Target Recruit Count
90
Registration Number
NCT03925740
Locations
🇸🇦

King Adbulaziz University Dental Hospital, Jeddah, Makkah, Saudi Arabia

Effectiveness Fluoride Varnishes in Children With Early Childhood Caries

Not Applicable
Completed
Conditions
Early Childhood Caries
Interventions
Drug: Sodium Fluoride with TCP
Drug: Sodium Fluoride with CXP
Drug: Sodium Fluoride with CPP-ACP
First Posted Date
2018-08-10
Last Posted Date
2018-08-10
Lead Sponsor
Merve Erkmen Almaz
Target Recruit Count
88
Registration Number
NCT03625310

A Study to Assess Efficacy of an Experimental Oral Rinse in Providing Long Term Relief From Dentinal Hypersensitivity

Phase 2
Completed
Conditions
Dentin Sensitivity
Interventions
Device: Potassium oxalate
Other: Placebo
First Posted Date
2017-08-03
Last Posted Date
2018-11-14
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
89
Registration Number
NCT03238352
Locations
🇺🇸

GSK Investigational Site, Fort Wayne, Indiana, United States

Livionex Oral Microbiome and Dental Plaque Control in HSCT Recipients

Phase 4
Recruiting
Conditions
Dental Plaque
Interventions
Drug: Livionex® Dental Gel
Device: Kolibree Toothbrush
First Posted Date
2015-12-01
Last Posted Date
2024-04-05
Lead Sponsor
University of California, San Francisco
Target Recruit Count
75
Registration Number
NCT02617407
Locations
🇺🇸

University of California, San Francisco, California, United States

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