Modafinil
- Generic Name
- Modafinil
- Brand Names
- Provigil
- Drug Type
- Small Molecule
- Chemical Formula
- C15H15NO2S
- CAS Number
- 68693-11-8
- Unique Ingredient Identifier
- R3UK8X3U3D
- Background
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactiva...
- Indication
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
- Associated Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Fatigue, Major Depressive Disorder (MDD), Narcolepsy, Obstructive Sleep Apnea (OSA), Shift-work related sleep disturbance
- Associated Therapies
- -
MIND Diet and Cognitive Decline; Gene Therapy for Parkinson's; Curbing MS Fatigue
The MIND diet slowed cognitive decline in older adults, but varied with lifestyle and vascular factors. Genetic effects on brain volumes were identified in ADHD and Parkinson's. AAV-GAD gene therapy showed safety and motor improvement in a Parkinson's trial. CVN424 reduced 'off' time in Parkinson's. A tool predicts epilepsy risk after cerebral venous sinus thrombosis. Experts identified eight headache research priorities. Modafinil and cognitive behavioral therapy had similar effects on MS fatigue. Anti-tumor necrosis factor therapy increased risk of inflammatory CNS diseases. Mailed educational interventions failed to reduce inappropriate prescribing in Alzheimer's and dementia.
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