Hyaluronic acid
- Generic Name
- Hyaluronic acid
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C28H44N2O23
- CAS Number
- 9004-61-9
- Unique Ingredient Identifier
- S270N0TRQY
- Background
Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluronic acid”. HA is involved in many important physiological processes, including but not limited to woun...
- Indication
The intra-articular preparations of hyaluronic acid are indicated for knee pain associated with osteoarthritis. Hyaluronic acid is used in cosmetic applications to prevent and reduce the appearance of wrinkles on the face, and as a dermal filler to correct facial imperfections or other imperfections on other parts of the body. It is frequently an ingredient ...
- Associated Conditions
- Actinic Keratosis (AK), Burns, Chronic Skin Ulcers, Conjunctivitis, Dehydration, Dermabrasion, Dermatosis, Dry Eyes, Facial Defect, Interstitial Cystitis, Keratoconjunctivitis, Ocular Irritation, Osteoarthritis (OA), Pain of the knee, Seasonal Allergic Conjunctivitis, Skin Burn, Skin Irritation, Skin fissures, Tissue Adhesions, Varicose Ulcers, Wound, Eye discomfort, Facial fine wrinkling, Sensation of burning in the eyes, Superficial Wounds
- Associated Therapies
- Dermal Filler, Promotion of wound healing, Synovial Fluid Lubrication
Efficacy of 3 Weekly Injections of Hyaluronate in Patients With Ankle Osteoarthritis
- First Posted Date
- 2009-06-11
- Last Posted Date
- 2009-06-17
- Lead Sponsor
- Kaohsiung Veterans General Hospital.
- Target Recruit Count
- 46
- Registration Number
- NCT00918736
- Locations
- 🇨🇳
Department of Physical Medicine and Rehabilitation, Veterans General Hospital, Kaohsiung, Taiwan, Kaohsiung, Taiwan
To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery.
- First Posted Date
- 2008-09-30
- Last Posted Date
- 2012-01-24
- Lead Sponsor
- Alcon Research
- Target Recruit Count
- 184
- Registration Number
- NCT00763360
- Locations
- 🇺🇸
Alcon Call Center, Fort Worth, Texas, United States
Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms
- Conditions
- Interventions
- First Posted Date
- 2008-09-29
- Last Posted Date
- 2013-11-19
- Lead Sponsor
- Allergan
- Target Recruit Count
- 50
- Registration Number
- NCT00761202
Gait Patterns After Intraarticular Treatment of Patients With Osteoarthritis of the Knee
- First Posted Date
- 2008-08-08
- Last Posted Date
- 2008-08-08
- Lead Sponsor
- Philipps University Marburg Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT00731289
- Locations
- 🇩🇪
Department of Orthopaedics, Movement Analysis Lab, University Hospital Münster, Germany, Muenster, Germany
Preparation Rich in Growth Factors (PRGF) Treatment for Osteoarthritis of the Knee
- Conditions
- Interventions
- First Posted Date
- 2008-08-06
- Last Posted Date
- 2011-07-12
- Lead Sponsor
- Meir Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT00728611
- Locations
- 🇮🇱
Meir Medical Center, Kfar Saba, Israel
Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome
- First Posted Date
- 2008-01-24
- Last Posted Date
- 2009-01-09
- Lead Sponsor
- Lantibio
- Target Recruit Count
- 300
- Registration Number
- NCT00599716
- Locations
- 🇺🇸
Comprehensive Eye Care, Washington, Missouri, United States
🇺🇸Center for Excellence in Eye Care, Miami, Florida, United States
🇺🇸Chattanooga Eye Institute, Chattanooga, Tennessee, United States
A Prospective Study of the Effect of Topical Sodium Hyaluronate Immediately Post-PKP on Time to Reepithelialization
- First Posted Date
- 2007-12-11
- Last Posted Date
- 2008-08-07
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 50
- Registration Number
- NCT00570648
- Locations
- 🇺🇸
University of Virginia, Charlottesville, Virginia, United States
HUPS: Hyalgan Use in Painful Shoulder
- Conditions
- First Posted Date
- 2006-09-18
- Last Posted Date
- 2011-01-11
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 602
- Registration Number
- NCT00377624
- Locations
- 🇺🇸
Sanofi-Aventis, Bridgewater, New Jersey, United States
The Efficacy Study of Sodium Hyaluronate to Treat Symptomatic Hip Osteoarthritis
- Conditions
- Interventions
- First Posted Date
- 2006-05-25
- Last Posted Date
- 2008-01-09
- Lead Sponsor
- Daiichi Sankyo
- Target Recruit Count
- 85
- Registration Number
- NCT00330135
A Phase I/II Study of Chondrogen Delivered by Intra-Articular Injection Following Meniscectomy
- Conditions
- Interventions
- First Posted Date
- 2005-09-23
- Last Posted Date
- 2021-12-27
- Lead Sponsor
- Mesoblast International Sàrl
- Target Recruit Count
- 60
- Registration Number
- NCT00225095
- Locations
- 🇺🇸
Orthopedic Center of Vero Beach, Vero Beach, Florida, United States
🇺🇸Ortholndy, Indianapolis, Indiana, United States
🇺🇸Greater Chesapeake Associates, Baltimore, Maryland, United States
Drug Development Updates
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