Hyaluronic acid

Generic Name: Hyaluronic acid

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₈H_₄₄N_₂O_₂₃

CAS Number: 9004-61-9

Unique Ingredient Identifier: S270N0TRQY

Background: Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluronic acid”. HA is involved in many important physiological processes, including but not limited to woun...

Indication: The intra-articular preparations of hyaluronic acid are indicated for knee pain associated with osteoarthritis. Hyaluronic acid is used in cosmetic applications to prevent and reduce the appearance of wrinkles on the face, and as a dermal filler to correct facial imperfections or other imperfections on other parts of the body. It is frequently an ingredient ...

Associated Conditions: Actinic Keratosis (AK), Burns, Chronic Skin Ulcers, Conjunctivitis, Dehydration, Dermabrasion, Dermatosis, Dry Eyes, Facial Defect, Interstitial Cystitis, Keratoconjunctivitis, Ocular Irritation, Osteoarthritis (OA), Pain of the knee, Seasonal Allergic Conjunctivitis, Skin Burn, Skin Irritation, Skin fissures, Tissue Adhesions, Varicose Ulcers, Wound, Eye discomfort, Facial fine wrinkling, Sensation of burning in the eyes, Superficial Wounds

Associated Therapies: Dermal Filler, Promotion of wound healing, Synovial Fluid Lubrication

Clinical Trials

Effect of Various Treatment Modalities on Dendritic Vial Ulcer

Conditions: Corneal Ulcer

Interventions: Drug: Acyclovir
Drug: Tobramycin
Drug: Sodium Hyaluronate
Drug: Fluorometholone

First Posted Date: 2022-04-06

Last Posted Date: 2022-04-06

Lead Sponsor: Sohag University

Target Recruit Count: 40

Registration Number: NCT05313828

Locations: 🇪🇬
Sohag University, Sohag, Egypt

Ultrasound-guided Injection of Glucocorticoid Into Infrapatellar Fat Pad in Patients With Knee Osteoarthritis

Phase 4

Completed

Conditions: Osteoarthritis, Knee

Interventions: Drug: Saline
Drug: Glucocorticoids
Drug: Hyaluronic acid

First Posted Date: 2022-03-23

Last Posted Date: 2024-12-05

Lead Sponsor: Zhujiang Hospital

Target Recruit Count: 60

Registration Number: NCT05291650

Locations: 🇨🇳
Zhujiang Hospital, Guangzhou, China

The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline

Not Applicable

Conditions: Wound Heal

Interventions: Drug: Hyaluronic acid
Dietary Supplement: honey

First Posted Date: 2021-12-17

Last Posted Date: 2021-12-17

Lead Sponsor: Cairo University

Target Recruit Count: 39

Registration Number: NCT05161403

Clinical and Radiographic Evaluation of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic Paste in Lesion Sterilization and Tissue Repair Technique for Non-Vital Primary Molars

Phase 3

Not yet recruiting

Conditions: Resorption of Tooth or Root

Interventions: Drug: Propylene glycol
Drug: Hyaluronic acid

First Posted Date: 2021-11-11

Last Posted Date: 2021-11-11

Lead Sponsor: Ain Shams University

Target Recruit Count: 36

Registration Number: NCT05116306

Multicenter Clinical Trial Comparing Treatment with Allogeneic Mesenchymal Cells Versus Autologous Mesenchymal Cells and Versus Active Control with Hyaluronic Acid in Patients with Knee Osteoarthritis.

Phase 3

Active, not recruiting

Conditions: Knee Osteoarthritis

Interventions: Drug: Autologous MSCs
Drug: Allogenic MSCs
Drug: Hyaluronic Acid

First Posted Date: 2021-10-21

Last Posted Date: 2024-11-28

Lead Sponsor: Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León

Target Recruit Count: 124

Registration Number: NCT05086939

Locations: 🇪🇸
Hospital Clínico Universitario San Carlos, Madrid, Spain
🇪🇸
Hospital Fundación Jiménez Díaz, Madrid, Spain
🇪🇸
Hospital Clinic, Barcelona, Spain

and more 5 locations

Chondrochymal® for Subjects With Knee Osteoarthritis (Knee OA)

Phase 2

Active, not recruiting

Conditions: Osteoarthritis, Knee

Interventions: Drug: Bone marrow mesenchymal stem cells
Drug: hyaluronic acid

First Posted Date: 2021-08-30

Last Posted Date: 2024-11-21

Lead Sponsor: Taiwan Bio Therapeutics Inc.

Target Recruit Count: 72

Registration Number: NCT05027581

Locations: 🇨🇳
Taipei Veterans General Hospital, Taipei, Beitou District, Taiwan
🇨🇳
Taipei Municipal Wangfang Hospital (Managed by Taipei Medical University), Taipei, Wenshan District, Taiwan