Chlorhexidine

Generic Name: Chlorhexidine

Brand Names: Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₃₀Cl_₂N_₁₀

CAS Number: 55-56-1

Unique Ingredient Identifier: R4KO0DY52L

Background: Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication: Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions: Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation

Associated Therapies: Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection

Clinical Trials

Evaluation of a Staphylococcus Eradication Protocol for Patients Who Present to the ED With Cutaneous Abscess

Phase 4

Completed

Conditions: Cutaneous Abscess

Interventions: Drug: Chlorhexidine gluconate
Drug: Mupirocin

First Posted Date: 2012-02-23

Last Posted Date: 2017-04-13

Lead Sponsor: Tufts Medical Center

Target Recruit Count: 50

Registration Number: NCT01537783

Locations: 🇺🇸
Tufts Medical Center, Boston, Massachusetts, United States

Study of Chlorhexidine Gluconate as a Preoperative Antisepsis

Phase 3

Completed

Conditions: Surgical Site Infection

Interventions: Drug: Chlorhexidine gluconate
Drug: Povidone-Iodine

First Posted Date: 2011-12-19

Last Posted Date: 2016-12-21

Lead Sponsor: Seung Duk Lee

Target Recruit Count: 534

Registration Number: NCT01495117

Locations: 🇰🇷
National Cancer Center, Republic of Korea, Goyang-si, Gyeonggi-do, Korea, Republic of

Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma

Not Applicable

Completed

Conditions: Ventilator Associated Pneumonia

Interventions: Other: Toothpaste
Drug: Chlorhexidine gluconate

First Posted Date: 2011-06-27

Last Posted Date: 2017-02-06

Lead Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Target Recruit Count: 66

Registration Number: NCT01382446

Locations: 🇺🇸
St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States

A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions

Not Applicable

Completed

Conditions: Bacteremia

Interventions: Drug: Iodine tincture
Drug: Chlorhexidine gluconate
Drug: Povidone iodine

First Posted Date: 2010-10-07

Last Posted Date: 2017-01-11

Lead Sponsor: University of Michigan

Target Recruit Count: 3879

Registration Number: NCT01216761

Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study

Phase 4

Completed

Conditions: This Study Evaluated the Effectiveness of Chlorhexidine Mouthrinse on Subgingival Microbiota

Interventions: Drug: Placebo mouthrinse
Drug: Chlorhexidine gluconate

First Posted Date: 2010-10-04

Last Posted Date: 2010-10-04

Lead Sponsor: Ege University

Target Recruit Count: 50

Registration Number: NCT01213550

Locations: 🇹🇷
Ege U School of Dentistry, Izmir, Bornova, Turkey
🇹🇷
Ege University School of Dentistry Dep of Periodontology, Izmir, Bornova, Turkey