Overview
Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate. Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. Cisatracurium is an R-cis-R-cis isomer of atracurium and has approximately 3 times its neuromuscular blocking potency. Compared to atracurium, cisatracurium produces a lower degree of histamine release.
Indication
Cisatracurium is indicated as an adjunct to general anesthesia to facilitate tracheal intubation in adults and pediatric patients 1 month to 12 years of age. Cisatracurium is also indicated to provide skeletal muscle relaxation during surgery in adults and pediatric patients 2 to 12 years of age as a bolus or infusion maintenance and for mechanical ventilation in the ICU in adults.
Associated Conditions
No associated conditions information available.
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2021/06/10 | N/A | Completed | Matias Vested | ||
2019/04/05 | Phase 2 | Completed | |||
2019/02/06 | N/A | Completed | Federal University of Minas Gerais | ||
2019/01/16 | Not Applicable | Completed | |||
2017/11/09 | Phase 4 | Completed | |||
2016/09/26 | N/A | Completed | Jakob Louis Thomsen | ||
2016/09/21 | Not Applicable | Completed | Zhihong LU | ||
2016/07/21 | Not Applicable | Completed | Silesian University of Medicine | ||
2016/06/28 | Phase 4 | UNKNOWN | |||
2015/12/21 | Phase 4 | Completed |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Civica, Inc. | 72572-067 | INTRAVENOUS | 10 mg in 1 mL | 4/13/2022 | |
| Meitheal Pharmaceuticals Inc. | 71288-713 | INTRAVENOUS | 200 mg in 20 mL | 5/31/2019 | |
| Caplin Steriles Limited | 65145-135 | INTRAVENOUS | 2 mg in 1 mL | 6/13/2023 | |
| Hospira, Inc. | 0409-1098 | INTRAVENOUS | 2 mg in 1 mL | 12/5/2022 | |
| Zydus Pharmaceuticals USA Inc. | 70710-1533 | INTRAVENOUS | 2 mg in 1 mL | 11/14/2022 | |
| Meitheal Pharmaceuticals Inc. | 71288-714 | INTRAVENOUS | 20 mg in 10 mL | 4/20/2023 | |
| Zydus Lifesciences Limited | 72785-0011 | INTRAVENOUS | 2 mg in 1 mL | 10/17/2022 | |
| Hikma Pharmaceuticals USA Inc. | 0143-9396 | INTRAVENOUS | 2 mg in 1 mL | 3/15/2023 | |
| Sagent Pharmaceuticals | 25021-668 | INTRAVENOUS | 2 mg in 1 mL | 9/8/2020 | |
| Zydus Lifesciences Limited | 72785-0008 | INTRAVENOUS | 2 mg in 1 mL | 11/5/2022 |
EMA Drug Approvals
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| No EMA approvals found for this drug. | |||
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| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
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UK EMC Drug Information
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| No UK EMC drug information found for this drug. | |||||
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