Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction
- Conditions
- Interventions
- First Posted Date
- 2014-08-15
- Last Posted Date
- 2017-09-12
- Lead Sponsor
- Collegium Medicum w Bydgoszczy
- Target Recruit Count
- 74
- Registration Number
- NCT02217878
- Locations
- 🇵🇱
Cardiology Department, Dr. A. Jurasz University Hospital, Bydgoszcz, Kujawsko-pomorskie, Poland
Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-08-11
- Last Posted Date
- 2016-07-13
- Lead Sponsor
- American University of Beirut Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT02213159
- Locations
- 🇱🇧
American University of Beirut Medical Center, Beirut, Lebanon
Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia.
- Conditions
- Interventions
- First Posted Date
- 2014-07-23
- Last Posted Date
- 2018-02-05
- Lead Sponsor
- University Hospital, Toulouse
- Target Recruit Count
- 680
- Registration Number
- NCT02198378
- Locations
- 🇫🇷
Centre Hospitalier Louis Pasteur, Chartres, France
🇫🇷Centre Hospitalier Dijon, Dijon, France
🇫🇷Centre Hospitalier Jean Minjoz, Besançon, France
Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management
- Conditions
- Interventions
- First Posted Date
- 2014-07-11
- Last Posted Date
- 2015-03-18
- Lead Sponsor
- Hamad Medical Corporation
- Target Recruit Count
- 1645
- Registration Number
- NCT02187614
- Locations
- 🇶🇦
Emergency Department, Hamad General Hospital., Doha, Qatar
Acupuncture Versus IV Morphine in the Treatment of Acute Pain in ED
- First Posted Date
- 2014-06-02
- Last Posted Date
- 2016-06-20
- Lead Sponsor
- University of Monastir
- Target Recruit Count
- 100
- Registration Number
- NCT02152410
- Locations
- 🇹🇳
university of Monastir, Monastir, Non-US/Canada, Tunisia
🇹🇳Fattouma Bourguiba University Hospital, Monastir, Tunisia
Post Operative Pain Control: Morphine vs Fentanyl
- First Posted Date
- 2014-05-26
- Last Posted Date
- 2014-05-26
- Lead Sponsor
- Catholic University of the Sacred Heart
- Target Recruit Count
- 60
- Registration Number
- NCT02146638
- Locations
- 🇮🇹
catholic University of the sacred Heart, Rome, Italy
Efficacy of Fentanyl to Reduce the Time of Severe Postoperative Pain Relief Compared to Morphine
- First Posted Date
- 2014-05-23
- Last Posted Date
- 2014-05-23
- Lead Sponsor
- Universidad de Antioquia
- Target Recruit Count
- 60
- Registration Number
- NCT02145975
- Locations
- 🇨🇴
Antioquia University, Medellin, Antioquia, Colombia
Low Pain Prediction in Cesarean Section Patients
- Conditions
- Interventions
- First Posted Date
- 2014-05-20
- Last Posted Date
- 2018-09-10
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 13
- Registration Number
- NCT02143141
- Locations
- 🇺🇸
Forsyth Medical Center, Winston-Salem, North Carolina, United States
Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals
- First Posted Date
- 2014-05-13
- Last Posted Date
- 2014-05-13
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 12
- Registration Number
- NCT02136784
- Locations
- 🇺🇸
UCLA Integrated Substance Abuse Programs Outpatient Clinical Research Center, Los Angeles, California, United States
Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status
- First Posted Date
- 2014-05-09
- Last Posted Date
- 2014-05-09
- Lead Sponsor
- Xiangya Hospital of Central South University
- Target Recruit Count
- 80
- Registration Number
- NCT02135055
Drug Development Updates
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