Fluticasone propionate

Generic Name: Fluticasone propionate

Brand Names: Advair, Airduo, Airduo Respiclick, Aller-flo, Armonair, Beser, Cutivate, Dymista, Flonase, Flovent, Fluticare, Ticanase, Wixela, Xhance

Drug Type: Small Molecule

Chemical Formula: C_₂₅H_₃₁F_₃O_₅S

CAS Number: 80474-14-2

Unique Ingredient Identifier: O2GMZ0LF5W

Background: Fluticasone propionate is a synthetic glucocorticoid. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications. Fluticasone propionate was first approved in 1990.

Indication: Fluticasone propionate is indicated as an inhaler for the treatment and management of asthma by prophylaxisas well as inflammatory and pruritic dermatoses. Fluticasone propionate nasal spray is indicated for managing allergic and nonallergic rhinitis.

Associated Conditions: Allergic Rhinitis (AR), Allergy to Animal Dander, Allergy to Mold, Allergy to Tree Pollen, Asthma, Bacterial Sinusitis, Chronic Bronchitis, Chronic Obstructive Pulmonary Disease (COPD), Chronic Sinusitis, Dermatitis, Emphysema, Eosinophilic Esophagitis, House Dust Mite Allergy, House dust allergy, Itching of the nose, Nasal Congestion, Non-Allergic Rhinitis, Rhinitis, Rhinitis Perennial, Rhinorrhoea, Seasonal Allergic Rhinitis, Sneezing, Moderate, severe Perennial Allergic Rhinitis (PAR), Moderate, severe Seasonal Allergic Rhinitis

Associated Therapies: -

Clinical Trials

A Comparative Study of Mometasone Furoate Nasal Spray and Fluticasone Propionate Nasal Spray in Patients With Perennial Allergic Rhinitis (Study P04512)

Phase 3

Completed

Conditions: Perennial Allergic Rhinitis

Interventions: Drug: Placebo for MF
Drug: Placebo for FP
Drug: Mometasone
Drug: Fluticasone

First Posted Date: 2008-10-31

Last Posted Date: 2022-02-09

Lead Sponsor: Organon and Co

Target Recruit Count: 351

Registration Number: NCT00783224

A Study Evaluating Systemic Exposure and Pharmacodynamics in Patients With Chronic Obstructive Pulmonary Disease

Phase 2

Completed

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Drug: fluticasone propionate/formoterol fumarate
Drug: formoterol fumarate
Drug: fluticasone propionate

First Posted Date: 2008-10-17

Last Posted Date: 2013-05-20

Lead Sponsor: Dey

Target Recruit Count: 97

Registration Number: NCT00774761

Locations: 🇺🇸
Investigative Site, Tacoma, Washington, United States

Elocon vs Fluticasone in Localized Psoriasis (P03197)

Phase 4

Completed

Conditions: Psoriasis

Interventions: Drug: Mometasone
Drug: Fluticasone

First Posted Date: 2008-10-01

Last Posted Date: 2024-08-15

Lead Sponsor: Organon and Co

Target Recruit Count: 245

Registration Number: NCT00763529

Effect of Intranasal Corticosteroids on Systemic Allergen Specific IgE

Not Applicable

Completed

Conditions: Seasonal Allergic Rhinitis

Interventions: Drug: Placebo
Drug: Fluticasone propionate

First Posted Date: 2008-09-18

Last Posted Date: 2008-09-26

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 48

Registration Number: NCT00755066

Locations: 🇦🇹
Allergy Centre Vienna West, Vienna, Austria

A Study Evaluating the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies

Phase 3

Completed

Conditions: Seasonal Allergic Rhinitis

Interventions: Drug: azelastine HCl/fluticasone propionate
Drug: azelastine Hcl
Drug: fluticasone propionate
Drug: placebo

First Posted Date: 2008-08-25

Last Posted Date: 2012-09-07

Lead Sponsor: Meda Pharmaceuticals

Target Recruit Count: 776

Registration Number: NCT00740792

Locations: 🇺🇸
Allergy, Asthma and Immunology Associates, Scottsdale, Arizona, United States
🇺🇸
Northeast Medical Research Associates, North Dartmouth, Massachusetts, United States
🇺🇸
Princeton Center for Clinical Research, Skillman, New Jersey, United States

and more 35 locations

The Effects of Montelukast on Smokers With Asthma

Phase 4

Completed

Conditions: Asthmatic Smokers
Non-asthmatic Smokers

Interventions: Drug: Fluticasone Propionate
Drug: Montelukast
Drug: Salmeterol

First Posted Date: 2008-07-09

Last Posted Date: 2012-05-16

Lead Sponsor: Inje University

Target Recruit Count: 105

Registration Number: NCT00712335

Locations: 🇰🇷
Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea, Republic of

The Effects of Different Long-acting Bronchodilator Medications on Asthma Patients With Different Genetic Variations

Not Applicable

Terminated

Conditions: Asthma

Interventions: Drug: tiotropium bromide
Drug: Salmeterol
Drug: Formoterol
Drug: budesonide
Drug: Fluticasone propionate

First Posted Date: 2008-06-27

Last Posted Date: 2017-05-31

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 255

Registration Number: NCT00706446

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

MethaCholine Bronchoprovocation Study (MeCIS)

Phase 4

Completed

Conditions: Asthma

Interventions: Drug: fluticasone

First Posted Date: 2008-06-26

Last Posted Date: 2013-02-12

Lead Sponsor: Johns Hopkins Bloomberg School of Public Health

Target Recruit Count: 219

Registration Number: NCT00705341

Locations: 🇺🇸
Washington University School of Medicine, St. Louis, Missouri, United States
🇺🇸
University of Miami/Univestiy of South Florida, Miami, Florida, United States
🇺🇸
Northwestern University Memorial Hospital, Chicago, Illinois, United States

and more 10 locations