Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.
On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.
Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.
The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.
Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.
As ibuprofen is a widely used medication, the main therapeutic indications are:
Pediatric Research Ward at Queen Elizabeth Central Hospital, Blantyre, Malawi
Chipata Central Hospital, Chipata, Eastern, Zambia
University Teaching Hospital's Lusaka Childrens Hospital, Lusaka, Zambia
Rady's Children's Hospital, San Diego, California, United States
Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Case Western University- Raimbow Babies and Children's, Cleveland, Ohio, United States
The University of Texas Health Science Center at Houston, Houston, Texas, United States
Dell Children's Medical Center, Austin, Texas, United States
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Saint Luke's Mountain States Tumor Institute - Nampa, Nampa, Idaho, United States
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States
Illinois CancerCare-Galesburg, Galesburg, Illinois, United States
Faculty of Dentistry, Cairo, Egypt
White Mountain Research Station, Bishop, California, United States
University of Florida, Jacksonville, Florida, United States
Wolfson Children's Hospital, Jacksonville, Florida, United States
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