Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Lidocaine Infusion for Pain After Herniotomy

First Posted Date
2018-09-17
Last Posted Date
2018-11-07
Lead Sponsor
Guangzhou First People's Hospital
Target Recruit Count
180
Registration Number
NCT03673163
Locations
🇨🇳

Guangzhou First People's Hospital, Guangzhou, Guangdong, China

Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery

First Posted Date
2018-09-12
Last Posted Date
2021-07-28
Lead Sponsor
Miodrag Filipovic, Prof. Dr. med.
Target Recruit Count
140
Registration Number
NCT03667001
Locations
🇨🇭

Cantonal Hospital of St. Gallen, St. Gallen, Switzerland

Sphenopalatine Ganglion Blocks RCT

First Posted Date
2018-09-12
Last Posted Date
2021-10-11
Lead Sponsor
University of California, San Francisco
Target Recruit Count
10
Registration Number
NCT03666663
Locations
🇺🇸

UCSF Headache Center, San Francisco, California, United States

Lidocaine Infusion for Postthoracotomy Pain Syndrome

First Posted Date
2018-09-11
Last Posted Date
2018-11-07
Lead Sponsor
Guangzhou First People's Hospital
Target Recruit Count
72
Registration Number
NCT03666299
Locations
🇨🇳

Guangzhou First People's Hospital, Guangzhou, Guangdong, China

Dysport in Post-Surgical Neuralgia

First Posted Date
2018-09-10
Last Posted Date
2021-01-12
Lead Sponsor
Ipsen
Target Recruit Count
16
Registration Number
NCT03663101
Locations
🇬🇧

St Pancras Clinical Research, London, United Kingdom

Pain Perception During Vulvar Biopsy

First Posted Date
2018-08-31
Last Posted Date
2020-01-18
Lead Sponsor
Duke University
Target Recruit Count
37
Registration Number
NCT03654417
Locations
🇺🇸

Duke Univeristy, Durham, North Carolina, United States

Onset and Duration of Forearm Nerve Blockade

Phase 4
Completed
Conditions
Interventions
First Posted Date
2018-08-28
Last Posted Date
2019-02-26
Lead Sponsor
New York School of Regional Anesthesia
Target Recruit Count
36
Registration Number
NCT03649763
Locations
🇧🇪

Ziekenhuis Oost-Limburg, Genk, Limburg, Belgium

Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients

First Posted Date
2018-08-21
Last Posted Date
2018-11-21
Lead Sponsor
Cairo University
Target Recruit Count
36
Registration Number
NCT03640468
Locations
🇪🇬

Cairo University, Cairo, Egypt

Lidocaine and Analgesia After Laparoscopic Cholecystectomy

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2018-08-08
Last Posted Date
2022-04-05
Lead Sponsor
Larissa University Hospital
Target Recruit Count
98
Registration Number
NCT03620591
Locations
🇬🇷

University Hospital of Larissa, Larissa, Greece

Minimum Anaesthesia Concentration of Lidocaine Required for Sciatic Popliteal Block

Phase 4
Conditions
Interventions
First Posted Date
2018-08-03
Last Posted Date
2018-11-14
Lead Sponsor
Healthpoint Hospital
Target Recruit Count
50
Registration Number
NCT03613974
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