Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

The Effects of Lidocaine and Esmolol on Attenuation of Hemodynamic Response to Orotracheal Intubation

First Posted Date
2018-08-02
Last Posted Date
2019-05-29
Lead Sponsor
Hospital de Base
Target Recruit Count
80
Registration Number
NCT03612492
Locations
🇧🇷

Hospital de Base do Distrito Federal, Brasilia, DF, Brazil

Adjuvant to General Anesthesia in Patients Undergoing Major Abdominal Surgeries

First Posted Date
2018-07-26
Last Posted Date
2018-08-03
Lead Sponsor
Suez Canal University
Target Recruit Count
64
Registration Number
NCT03600493

Intravenous Lidocaine in Total Knee Replacement

Phase 4
Completed
Conditions
Interventions
First Posted Date
2018-07-24
Last Posted Date
2024-05-16
Lead Sponsor
The University of Hong Kong
Target Recruit Count
62
Registration Number
NCT03597776
Locations
🇭🇰

Queen Mary Hospital, Hong Kong, Hong Kong

A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin

First Posted Date
2018-07-16
Last Posted Date
2020-04-20
Lead Sponsor
Aalborg University
Target Recruit Count
44
Registration Number
NCT03587220
Locations
🇩🇰

Silvia Lo Vecchio, Aalborg, Nordjylland, Denmark

Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department

Phase 3
Conditions
Interventions
First Posted Date
2018-07-03
Last Posted Date
2021-01-05
Lead Sponsor
New York City Health and Hospitals Corporation
Target Recruit Count
50
Registration Number
NCT03576820
Locations
🇺🇸

Jacobi Medical Center, Bronx, New York, United States

A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing

First Posted Date
2018-07-03
Last Posted Date
2020-07-08
Lead Sponsor
Aalborg University
Target Recruit Count
59
Registration Number
NCT03576053
Locations
🇩🇰

Aalborg University, Aalborg, Nordjylland, Denmark

Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension

First Posted Date
2018-06-25
Last Posted Date
2019-08-15
Lead Sponsor
Ahmed Mohamed ELbadawy
Target Recruit Count
90
Registration Number
NCT03566329
Locations
🇪🇬

Ahmed ELbadawy, Cairo, Egypt

Lidocaine Reduces Muscle Tremor is Beneficial for Intraoperative Recurrent Laryngeal Nerve Monitoring

First Posted Date
2018-05-21
Last Posted Date
2018-09-18
Lead Sponsor
Bo Wang,MD
Target Recruit Count
40
Registration Number
NCT03530033
Locations
🇨🇳

Fujian Medical University Union Hospital, FuZhou, Fujian, China

The Value of Endocervical and Endometrial Lidocaine Flushing Before Office Hystroscopy

First Posted Date
2018-05-21
Last Posted Date
2018-05-21
Lead Sponsor
Cairo University
Target Recruit Count
250
Registration Number
NCT03530488
Locations
🇪🇬

Kasr Alainy medical school, Cairo, Egypt

Multimodal Analgesia Versus Traditional Opiate Based Analgesia

First Posted Date
2018-05-11
Last Posted Date
2018-05-11
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
225
Registration Number
NCT03521167
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