MedPath

Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Intravenous Lidocaine and Postoperative Outcomes After Cardiac Surgery

Not Applicable
Terminated
Conditions
Atrial Fibrillation
Interventions
Other: Placebo
Drug: Lidocaine
First Posted Date
2009-02-11
Last Posted Date
2019-03-29
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
123
Registration Number
NCT00840918
Locations
🇮🇳

SAL Hospital, Ahmedabad, Gujarat, India

Treatment for Achilles Tendinopathy

Phase 2
Conditions
Achilles Tendinopathy
Achilles Tendon Enthesopathy
Mid-Portion Achilles Tendinopathy
Insertional Achilles Tendinopathy
Non-Insertional Achilles Tendinopathy
Interventions
Drug: 25% Dextrose and 1% Lidocaine
Drug: Lidocaine
Procedure: sclerotherapy
First Posted Date
2009-02-04
Last Posted Date
2009-02-04
Lead Sponsor
University of Calgary
Target Recruit Count
17
Registration Number
NCT00835939
Locations
🇨🇦

University of Calgary, Calgary, Alberta, Canada

The Influence of Intravenous Lidocaine on the Action of the Neuromuscular Blocker Rocuronium

Phase 4
Completed
Conditions
Neuromuscular Block
Interventions
Drug: Placebo
Drug: Lidocaine
First Posted Date
2009-01-23
Last Posted Date
2011-07-15
Lead Sponsor
University Hospital, Geneva
Target Recruit Count
52
Registration Number
NCT00828373
Locations
🇨🇭

University Hospitals of Geneva, Geneva, Switzerland

Treatment Study of Steroid Injection and Physical Therapy for Acute Lateral Epicondylitis

Phase 4
Completed
Conditions
Tennis Elbow
Epicondylitis, Lateral Humeral
Interventions
Drug: Placebo
Drug: triamcinolone
Drug: Lidocaine
Other: Physiotherapy
Drug: Naproxen
First Posted Date
2009-01-22
Last Posted Date
2022-01-24
Lead Sponsor
University of Oslo
Target Recruit Count
177
Registration Number
NCT00826462
Locations
🇳🇴

Grålum legesenter, Sarpsborg, Norway

Effect of Intravesical Lidocaine on Urodynamic and Symptomatic Parameters of Interstitial Cystitis

Not Applicable
Withdrawn
Conditions
Interstitial Cystitis
Interventions
Procedure: Urodynamic study
Other: Normal Saline
Drug: Lidocaine
First Posted Date
2009-01-15
Last Posted Date
2015-10-14
Lead Sponsor
Northwell Health
Registration Number
NCT00823030
Locations
🇺🇸

Smith Institute for Urology, Lake Success, New York, United States

Percutaneous Ketamine Versus Lidocaine for Mid-Sternotomy

Phase 4
Conditions
Sternotomy
Interventions
Drug: ketamine
Drug: non-drug cream
Drug: lidocaine
First Posted Date
2009-01-14
Last Posted Date
2009-01-14
Lead Sponsor
Tel-Aviv Sourasky Medical Center
Target Recruit Count
75
Registration Number
NCT00822419
Locations
🇮🇱

Tel Aviv Sourasky Medical center, Tel Aviv, Israel

Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection

Phase 4
Conditions
Postoperative Pain
Interventions
Drug: non-active drug cream
Drug: lidocaine
Drug: ketamine
First Posted Date
2009-01-14
Last Posted Date
2009-01-14
Lead Sponsor
Tel-Aviv Sourasky Medical Center
Target Recruit Count
75
Registration Number
NCT00822133
Locations
🇮🇱

Tel Aviv Sourasky Medical center, Tel Aviv, Israel

Effects of Intravenous Lidocaine on Transperitoneal Laparoscopic Urological Surgery

Phase 3
Completed
Conditions
Pain
Fatigue
Interventions
Drug: lidocaine
Drug: placebo
First Posted Date
2008-11-13
Last Posted Date
2011-03-24
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
76
Registration Number
NCT00789620
Locations
🇨🇭

Dep. of Urology, Bern University Hospital, Bern, Switzerland

Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation

Phase 4
Completed
Conditions
Pain
Interventions
Drug: normal saline
Drug: lidocaine
First Posted Date
2008-11-06
Last Posted Date
2015-02-27
Lead Sponsor
Akron Children's Hospital
Target Recruit Count
109
Registration Number
NCT00786916
Locations
🇺🇸

Akron Children's Hospital, Akron, Ohio, United States

Hematoma Block as an Adjunct to Procedural Sedation for Forearm Fracture Reduction

Phase 4
Terminated
Conditions
Forearm Fracture
Interventions
Drug: Saline
Drug: Lidocaine
First Posted Date
2008-10-01
Last Posted Date
2013-11-19
Lead Sponsor
Rhode Island Hospital
Target Recruit Count
89
Registration Number
NCT00763880
Locations
🇺🇸

Hasbro Children's Hospital/Rhode Island Hospital, Providence, Rhode Island, United States

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