Tacrolimus
- Generic Name
- Tacrolimus
- Brand Names
- Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic, Tacforius
- Drug Type
- Small Molecule
- Chemical Formula
- C44H69NO12
- CAS Number
- 104987-11-3
- Unique Ingredient Identifier
- Y5L2157C4J
- Background
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condi...
- Indication
Immediate-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants, in combination with other immunosuppressants. Extended-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric ...
- Associated Conditions
- Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Kidney Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Oral Lichen Planus, Psoriasis, Pyoderma Gangrenosum, Rheumatoid Arthritis, Severe Atopic Dermatitis, Vitiligo, Moderate Atopic dermatitis
- Associated Therapies
- -
Steroid Withdrawal in Pediatric Kidney Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2016-10-21
- Target Recruit Count
- 274
- Registration Number
- NCT00023244
- Locations
- 🇺🇸
University of Florida Health Science Center, Jacksonville, Florida, United States
🇺🇸The Children's Hospital of Buffalo, Buffalo, New York, United States
🇺🇸Westchester Medical Center, Valhalla, New York, United States
Antibody and Delayed Cyclosporine Versus Initial Cyclosporine Alone in Patients Receiving Kidney Transplants
- Conditions
- Interventions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2013-01-23
- Target Recruit Count
- 350
- Registration Number
- NCT00007787
- Locations
- 🇺🇸
Ilene Blechman-Krom, Rockville, Maryland, United States
A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
- Conditions
- Interventions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2012-03-13
- Lead Sponsor
- Boston Children's Hospital
- Target Recruit Count
- 102
- Registration Number
- NCT00005113
- Locations
- 🇺🇸
Children's Hospital Boston, Boston, Massachusetts, United States
Islet Transplantation for Type 1 Diabetes
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2017-03-15
- Target Recruit Count
- 36
- Registration Number
- NCT00014911
- Locations
- 🇩🇪
Justus-Leibig University, Giessen, Germany
🇨🇦University of Alberta, Edmonton, Alberta, Canada
🇨🇭University of Geneva, Geneva, Switzerland
Drug Development Updates
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