Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including ...
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2014-01-06
- Lead Sponsor
- Herbert Irving Comprehensive Cancer Center
- Registration Number
- NCT00027833
- Locations
- 🇨🇦
Princess Margaret Hospital, Toronto, Ontario, Canada
🇺🇸USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States
🇺🇸Scranton Hematology-Oncology, Scranton, Pennsylvania, United States
Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer
- Conditions
- Interventions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2020-05-07
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 546
- Registration Number
- NCT00052910
- Locations
- 🇺🇸
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem, Ohio, United States
🇺🇸Kaiser Foundation Hospital - San Rafael, San Rafael, California, United States
🇺🇸Kinston Medical Specialists, Kinston, North Carolina, United States
Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2015-04-30
- Lead Sponsor
- National Cancer Institute (NCI)
- Registration Number
- NCT00020488
- Locations
- 🇺🇸
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda, Maryland, United States
Combination Chemotherapy in Treating Patients With Colon Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- Groupe Regional d'Etudes du Cancer Colorectal
- Target Recruit Count
- 800
- Registration Number
- NCT00046995
- Locations
- 🇧🇪
Clinique Saint-Joseph, Liege, Belgium
🇧🇪Centre Hospitalier Hutois, Huy, Belgium
Biological Therapy With Combination Chemotherapy in Patients With Colorectal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- European Institute of Oncology
- Target Recruit Count
- 1050
- Registration Number
- NCT00003063
- Locations
- 🇮🇹
Cattedra di Oncologia Medica - Universita, Cagliari, Italy
🇮🇹Ospedale Valduce, Como, Italy
🇮🇹Ospedale San Michele, Cagliari, Italy
Chemotherapy Plus Surgery in Treating Women With Breast Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Target Recruit Count
- 450
- Registration Number
- NCT00003013
- Locations
- 🇦🇹
Kaiser Franz Josef Hospital, Vienna, Austria
🇨🇿Radiotherapy Institute, Ostrava-Poruba, Czech Republic
🇸🇰St. Elizabeth Cancer Institute Hospital, Bratislava, Slovakia
Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2016-09-02
- Target Recruit Count
- 1011
- Registration Number
- NCT00002523
- Locations
- 🇧🇪
Hopital Universitaire Erasme, Brussels, Belgium
🇧🇪Hopital Civil de Charleroi, Charleroi, Belgium
🇧🇪Clinique Sainte Elisabeth, Namur, Belgium
Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer
- Conditions
- Interventions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-05
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 53
- Registration Number
- NCT00002951
- Locations
- 🇺🇸
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States
🇺🇸University of Chicago Cancer Research Center, Chicago, Illinois, United States
🇺🇸Louis A. Weiss Memorial Hospital, Chicago, Illinois, United States
Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-08-26
- Lead Sponsor
- University College London (UCL) Cancer Institute
- Target Recruit Count
- 600
- Registration Number
- NCT00025090
- Locations
- 🇬🇧
Cancer Research UK and University College London Cancer Trials Centre, London, England, United Kingdom
🇬🇧Northwick Park Hospital, Harrow, England, United Kingdom
🇬🇧Cookridge Hospital, Leeds, England, United Kingdom
Chemotherapy in Treating Patients With Cancer of Unknown Primary Origin
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-08-07
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Target Recruit Count
- 140
- Registration Number
- NCT00003558
- Locations
- 🇳🇱
St. Elisabeth Ziekenhuis, Tilburg, Netherlands
🇳🇱Academisch Ziekenhuis Maastricht, Maastricht, Netherlands
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.