Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including ...
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
Combination Chemotherapy Plus Radiation Therapy To Preserve the Larynx in Patients With Cancer of the Hypopharynx or Larynx
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2018-07-09
- Target Recruit Count
- 564
- Registration Number
- NCT00002839
- Locations
- 🇳🇱
Leiden University Medical Center, Leiden, Netherlands
🇮🇱Rambam Medical Center, Haifa, Israel
🇧🇪Algemeen Ziekenhuis Middelheim, Antwerp, Belgium
Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2017-01-04
- Lead Sponsor
- Radiation Therapy Oncology Group
- Target Recruit Count
- 682
- Registration Number
- NCT00003596
- Locations
- 🇺🇸
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University, Columbus, Ohio, United States
🇺🇸Riverside Methodist Hospital Cancer Care, Columbus, Ohio, United States
🇺🇸CCOP - Columbus, Columbus, Ohio, United States
Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2020-10-22
- Lead Sponsor
- Radiation Therapy Oncology Group
- Registration Number
- NCT00006366
- Locations
- 🇺🇸
CCOP - Columbus, Columbus, Ohio, United States
🇺🇸Mercy Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
🇨🇦Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2023-06-15
- Lead Sponsor
- Eastern Cooperative Oncology Group
- Registration Number
- NCT00049348
- Locations
- 🇺🇸
Mason District Hospital, Havana, Illinois, United States
🇺🇸Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸Hematology and Oncology Associates, Chicago, Illinois, United States
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2014-05-09
- Lead Sponsor
- Fox Chase Cancer Center
- Target Recruit Count
- 21
- Registration Number
- NCT00021320
- Locations
- 🇺🇸
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
UCN-01, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or Unresectable Solid Tumors
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2015-04-30
- Lead Sponsor
- National Cancer Institute (NCI)
- Registration Number
- NCT00042861
- Locations
- 🇺🇸
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda, Maryland, United States
Biological Therapy and Chemotherapy in Treating Patients With Metastatic Kidney Cancer or Colorectal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-06-26
- Lead Sponsor
- St. Luke's Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT00030342
- Locations
- 🇺🇸
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, United States
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2017-04-11
- Lead Sponsor
- City of Hope Medical Center
- Target Recruit Count
- 49
- Registration Number
- NCT00002842
- Locations
- 🇺🇸
City of Hope Comprehensive Cancer Center, Duarte, California, United States
Combination Chemotherapy in Treating Older Women With Metastatic Breast Cancer
- Conditions
- Locations
- 🇫🇷
Hopital Tenon, Paris, France
🇫🇷Centre Hospitalier Victor Dupouy, Argenteuil, France
🇫🇷Hopital Saint Antoine, Paris, France
Combination Chemotherapy in Treating Patients With Esophageal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-08-12
- Lead Sponsor
- Medical Research Council
- Target Recruit Count
- 1300
- Registration Number
- NCT00041262
- Locations
- 🇬🇧
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust, Birmingham, England, United Kingdom
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.