Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including ...

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

Combination Chemotherapy in Treating Women With Stage III Breast Cancer

Phase 3

Suspended

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-02

Lead Sponsor: Grupo Oncologico Cooperativo del Sur

Registration Number: NCT00002696

Locations: 🇦🇷
Unidad Oncologica Del Comahue, Neuquen, Argentina
🇦🇷
Centro De Oncologia y Terapia Radiante, Santa Rosa, La Pampa, Argentina
🇦🇷
Policlinica Privada Instituto De Medicina Nuclear, Bahia Blanca, Buenos Aires, Argentina

and more 3 locations

Combination Chemotherapy and Radiation Therapy in Treating Patients With Pancreatic Cancer

Phase 2

Completed

Conditions: Pancreatic Cancer

Interventions: Drug: fluorouracil
Drug: gemcitabine hydrochloride
Radiation: radiation therapy

First Posted Date: 2003-01-27

Last Posted Date: 2016-07-19

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 81

Registration Number: NCT00026130

Locations: 🇺🇸
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center, Los Angeles, California, United States
🇺🇸
Louis A. Weiss Memorial Hospital, Chicago, Illinois, United States
🇺🇸
Fort Wayne Medical Oncology and Hematology, Incorporated, Fort Wayne, Indiana, United States

and more 74 locations

Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

Phase 3

Completed

Conditions: Metastatic Cancer
Colorectal Cancer

Interventions: Drug: dexamethasone
Drug: fluorouracil
Drug: leucovorin calcium
Drug: floxuridine
Procedure: laparotomy
Procedure: conventional surgery

First Posted Date: 2003-01-27

Last Posted Date: 2016-07-13

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 135

Registration Number: NCT00002716

Locations: 🇺🇸
CCOP - Cedar Rapids Oncology Project, Cedar Rapids, Iowa, United States
🇺🇸
CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States
🇺🇸
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa, United States

and more 11 locations

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer

Phase 3

Completed

Conditions: Anal Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2021-02-17

Lead Sponsor: UNICANCER

Target Recruit Count: 350

Registration Number: NCT00003652

Locations: 🇫🇷
Centre Paul Papin, Angers, France
🇫🇷
Centre Regional Francois Baclesse, Caen, France
🇫🇷
Centre Hospitalier, Chalon Sur Saone, France

and more 45 locations

High-Dose Radiation Therapy Plus Chemotherapy in Treating Patients With Advanced Nose or Throat Cancer

Phase 1

Completed

Conditions: Head and Neck Cancer

Interventions: Drug: cisplatin
Drug: fluorouracil
Procedure: adjuvant therapy
Radiation: radiation therapy

First Posted Date: 2003-01-27

Last Posted Date: 2018-01-09

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Target Recruit Count: 25

Registration Number: NCT00052429

Locations: 🇺🇸
Memorial Sloan - Kettering Cancer Center, New York, New York, United States

Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer

Phase 2

Completed

Conditions: Gastric Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2020-10-19

Lead Sponsor: Radiation Therapy Oncology Group

Registration Number: NCT00003862

Locations: 🇺🇸
McLaren Regional Cancer Center, Flint, Michigan, United States
🇺🇸
Ireland Cancer Center, Cleveland, Ohio, United States
🇺🇸
Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, United States

and more 52 locations

Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer

Phase 3

Completed

Conditions: Breast Cancer

Interventions: Biological: filgrastim
Drug: docetaxel
Drug: cyclophosphamide
Genetic: microarray analysis
Drug: epirubicin hydrochloride
Drug: fluorouracil
Other: laboratory biomarker analysis
Other: immunohistochemistry staining method
Procedure: biopsy
Procedure: neoadjuvant therapy
Procedure: conventional surgery
Radiation: radiation therapy

First Posted Date: 2003-01-27

Last Posted Date: 2013-10-24

Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Target Recruit Count: 1856

Registration Number: NCT00017095

Locations: 🇬🇧
Edinburgh Cancer Centre at Western General Hospital, Edinburgh, Scotland, United Kingdom
🇵🇹
Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, S.A., Lisbon, Portugal
🇨🇭
Inselspital Bern, Bern, Switzerland

and more 36 locations

Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin

Phase 2

Completed

Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Colorectal Cancer
Carcinoma of Unknown Primary
Unspecified Adult Solid Tumor, Protocol Specific

First Posted Date: 2003-01-27

Last Posted Date: 2017-04-26

Lead Sponsor: St. Jude Children's Research Hospital

Target Recruit Count: 12

Registration Number: NCT00004005

Locations: 🇺🇸
St. Jude Children's Research Hospital, Memphis, Tennessee, United States

Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer

Phase 3

Completed

Conditions: Colorectal Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-12-19

Lead Sponsor: Medical Research Council

Registration Number: NCT00008060

Locations: 🇬🇧
Medical Research Council Clinical Trials Unit, London, England, United Kingdom

Surgery and Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer That Can Be Removed During Surgery

Phase 3

Completed

Conditions: Head and Neck Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-12-19

Lead Sponsor: National Cancer Centre, Singapore

Target Recruit Count: 200

Registration Number: NCT00003576

Locations: 🇸🇬
National Cancer Centre - Singapore, Singapore, Singapore

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