Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

Breast Cancer Treated by Neoadjuvant Chemotherapy

Phase 2

Completed

Conditions: Individualized Chemotherapy

Interventions: Drug: Taxotere
Drug: 5-Fluorouracil
Drug: Epirubicin
Drug: Cyclophosphamide

First Posted Date: 2007-01-23

Last Posted Date: 2014-10-01

Lead Sponsor: Centre Jean Perrin

Target Recruit Count: 264

Registration Number: NCT00425516

Locations: 🇫🇷
Hospital center, Brive La Gaillarde, France
🇫🇷
Centre Jean Perrin, Clermont Ferrand, France
🇫🇷
Edouard Herriot University Hospital, Lyon, France

and more 3 locations

Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer

Phase 3

Completed

Conditions: Colorectal Cancer

First Posted Date: 2007-01-22

Last Posted Date: 2010-02-08

Lead Sponsor: NSABP Foundation Inc

Target Recruit Count: 2151

Registration Number: NCT00425152

Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

Phase 2

Completed

Conditions: Colorectal Cancer

Interventions: Biological: bevacizumab
Drug: fluorouracil
Drug: capecitabine
Drug: irinotecan hydrochloride
Drug: leucovorin calcium

First Posted Date: 2007-01-18

Last Posted Date: 2021-02-17

Lead Sponsor: UNICANCER

Target Recruit Count: 145

Registration Number: NCT00423696

Locations: 🇫🇷
C.H.U. de Brest, Brest, France
🇫🇷
Centre Regional Francois Baclesse, Caen, France
🇫🇷
Centre Oscar Lambret, Lille, France

and more 12 locations

Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer

Phase 2

Completed

Conditions: Anal Cancer

Interventions: Drug: fluorouracil
Drug: mitomycin C
Radiation: Intensity-modulated radiation therapy

First Posted Date: 2007-01-18

Last Posted Date: 2019-02-27

Lead Sponsor: Radiation Therapy Oncology Group

Target Recruit Count: 63

Registration Number: NCT00423293

Locations: 🇺🇸
St. Mary - Corwin Regional Medical Center, Pueblo, Colorado, United States
🇺🇸
Genesys Hurley Cancer Institute, Flint, Michigan, United States
🇺🇸
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette, Wisconsin, United States

and more 169 locations