Methimazole
- Generic Name
- Methimazole
- Brand Names
- Tapazole
- Drug Type
- Small Molecule
- Chemical Formula
- C4H6N2S
- CAS Number
- 60-56-0
- Unique Ingredient Identifier
- 554Z48XN5E
- Background
Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.
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- Indication
In the United States, methimazole is indicated for the treatment of hyperthyroidism in patients with Graves' disease or toxic multinodular goiter for whom thyroidectomy or radioactive iodine therapy are not appropriate treatment options. Methimazole is also indicated for the amelioration of hyperthyroid symptoms in preparation for thyroidectomy or radioactiv...
- Associated Conditions
- Graves' Disease, Hyperthyroidism, Toxic multinodular goiter
- Associated Therapies
- -
Methimazole in Patients With Progressive Glioblastoma
- Conditions
- Interventions
- First Posted Date
- 2022-11-07
- Last Posted Date
- 2023-09-01
- Lead Sponsor
- Case Comprehensive Cancer Center
- Target Recruit Count
- 19
- Registration Number
- NCT05607407
- Locations
- 🇺🇸
Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Effects of Different Treatment Schemes on the Regulation and Recurrence of Graves' Disease
- Conditions
- Interventions
- First Posted Date
- 2022-07-18
- Last Posted Date
- 2023-12-11
- Target Recruit Count
- 240
- Registration Number
- NCT05461820
- Locations
- 🇨🇳
the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
- Conditions
- Interventions
- First Posted Date
- 2021-11-12
- Last Posted Date
- 2021-11-12
- Lead Sponsor
- Indonesia University
- Target Recruit Count
- 36
- Registration Number
- NCT05118542
- Locations
- 🇮🇩
University of Indonesia, Jakarta Pusat, Jakarta, Indonesia
Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma
- Conditions
- Interventions
- First Posted Date
- 2021-08-24
- Last Posted Date
- 2022-12-02
- Lead Sponsor
- Emory University
- Registration Number
- NCT05017610
A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy
- Conditions
- Interventions
- First Posted Date
- 2021-03-02
- Last Posted Date
- 2023-03-17
- Lead Sponsor
- University of Pisa
- Target Recruit Count
- 52
- Registration Number
- NCT04776993
- Locations
- 🇮🇹
Endocrinology Unit II, Pisa, PI, Italy
Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma
- First Posted Date
- 2020-04-15
- Last Posted Date
- 2020-05-06
- Lead Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
- Target Recruit Count
- 23
- Registration Number
- NCT04346901
- Locations
- 🇮🇩
dr. Cipto Mangunkusumo Hospital, Jakarta, Jakarta Pusat, Indonesia
Treatment of Graves' Hyperthyroidism With Selenium Plus Methimazole
- Conditions
- Interventions
- First Posted Date
- 2016-04-05
- Last Posted Date
- 2016-04-06
- Lead Sponsor
- University of Pisa
- Target Recruit Count
- 30
- Registration Number
- NCT02727738
- Locations
- 🇮🇹
Endocrinology Unit, Pisa, PI, Italy
Characteristics of Islet β-cell Functions in Chinese Patients With Graves' Disease
- First Posted Date
- 2015-03-03
- Last Posted Date
- 2015-03-03
- Lead Sponsor
- Weikai Hou
- Target Recruit Count
- 328
- Registration Number
- NCT02376088
Bromocriptine and Pentoxifylline in Ophthalmopathy Autoimmune Treatment
- Conditions
- Interventions
- First Posted Date
- 2013-07-09
- Last Posted Date
- 2013-07-09
- Target Recruit Count
- 31
- Registration Number
- NCT01893450
- Locations
- 🇲🇽
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico
Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone
- First Posted Date
- 2013-05-09
- Last Posted Date
- 2013-05-13
- Lead Sponsor
- Universidade Federal do Rio de Janeiro
- Target Recruit Count
- 200
- Registration Number
- NCT01849861
- Locations
- 🇧🇷
Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Drug Development Updates
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