Stavudine

Generic Name
Stavudine
Brand Names
Zerit
Drug Type
Small Molecule
Chemical Formula
C10H12N2O4
CAS Number
3056-17-5
Unique Ingredient Identifier
BO9LE4QFZF
Background

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Indication

For the treatment of human immunovirus (HIV) infections.

Associated Conditions
Human Immunodeficiency Virus (HIV) Infections
Associated Therapies
-

Double-Blind Study of Timunox (Thymopentin) in Asymptomatic HIV-Infected Patients Receiving Either Mono (AZT or ddI) or Combination (AZT / ddI or AZT / ddC) Anti-Retroviral Therapy

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Immunobiology Research Institute
Registration Number
NCT00002109
Locations
🇺🇸

Cleveland Clinic, Cleveland, Ohio, United States

🇺🇸

Fisher Med Group, Phoenix, Arizona, United States

🇺🇸

Ctr for Special Immunology, New York, New York, United States

and more 42 locations

Treatment With Combinations of Several Antiviral Drugs in Infants and Young Children With HIV Infection

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
55
Registration Number
NCT00000872
Locations
🇺🇸

Johns Hopkins Hosp. & Health System - Dept. of Peds., Div. of Infectious Diseases, Baltimore, Maryland, United States

🇺🇸

Univ. of Maryland Med. Ctr., Div. of Ped. Immunology & Rheumatology, Baltimore, Maryland, United States

🇺🇸

BMC, Div. of Ped Infectious Diseases, Boston, Massachusetts, United States

and more 9 locations

Evaluation of an Anti-HIV Drug Combination That Includes a Coated Form of Didanosine (ddI EC) Compared to a Typical Anti-HIV Drug Regimen

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2011-05-04
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
500
Registration Number
NCT00002429
Locations
🇺🇸

NJCRI, Newark, New Jersey, United States

🇺🇸

Univ of Texas Southwestern Med Ctr of Dallas, Dallas, Texas, United States

🇨🇦

Clinique Medicale L'Actuele, Montreal, Quebec, Canada

and more 20 locations

The Safety and Effectiveness of Lamivudine Plus Stavudine or Zidovudine in HIV-Infected Patients Who Have Taken Zidovudine

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2011-05-04
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
80
Registration Number
NCT00002371
Locations
🇺🇸

Harbor UCLA Med Ctr, Torrance, California, United States

🇺🇸

SUNY at Stony Brook / Division of Infectious Diseases, Stony Brook, New York, United States

🇨🇦

Montreal Gen Hosp / Div of Clin Immuno and Allergy, Montreal, Quebec, Canada

and more 5 locations

Safety and Effectiveness of Combining Hydroxyurea (HU) With Didanosine (ddI) and Stavudine (d4T) for Treatment of HIV-Infected Adults

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Research Institute for Genetic and Human Therapy
Target Recruit Count
225
Registration Number
NCT00002427
Locations
🇺🇸

Albany Med College, Albany, New York, United States

🇺🇸

Boulevard Comprehensive Care Ctr, Jacksonville, Florida, United States

🇺🇸

Gary Blick MD, Stamford, Connecticut, United States

and more 15 locations

The Effectiveness of HIV RNA Viral Load Testing in Determining Treatment Type in HIV-Infected Patients

Phase 4
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
540
Registration Number
NCT00002376
Locations
🇺🇸

Kaiser Foundation Hospital, San Francisco, California, United States

Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment

Phase 4
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Glaxo Wellcome
Target Recruit Count
300
Registration Number
NCT00005017
Locations
🇺🇸

Jaime Hernandez, Research Triangle Park, North Carolina, United States

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Dupont Merck
Target Recruit Count
60
Registration Number
NCT00002227
Locations
🇺🇸

The Whitman Walker Clinic, Washington, District of Columbia, United States

🇺🇸

Richard Elion, Washington, District of Columbia, United States

🇺🇸

Montrose Clinic, Houston, Texas, United States

and more 5 locations

A Randomized, Parallel Arm, Comparative, Open Label, Multicenter Study of the Activity and Safety of Two Formulations of Saquinavir in Combination With Other Antiretroviral Drugs

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
140
Registration Number
NCT00002162
Locations
🇺🇸

UCD Med Ctr, Sacramento, California, United States

🇺🇸

Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States

🇺🇸

UCSD Treatment Ctr, San Diego, California, United States

and more 24 locations

A Phase II, Stratified, Randomized, Double-Blind, Multi-Center Study of the Safety and Efficacy of Adefovir Dipivoxil (ADF) at Two Dose Levels in Triple Combination Therapies With Protease Inhibitors (PI) and Nucleoside Reverse Transcriptase Inhibitors (RTI) for the Treatment of HIV-Infected Patient

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Gilead Sciences
Target Recruit Count
120
Registration Number
NCT00002184
Locations
🇺🇸

Krauss Med Partners / Dept of Research and Development, Los Angeles, California, United States

🇺🇸

UCLA Care Ctr, Los Angeles, California, United States

🇵🇷

Hosp Regional de Ponce - Area Vieja, Ponce, Puerto Rico

and more 12 locations
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