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Nitrofurantoin

Generic Name
Nitrofurantoin
Brand Names
Furadantin, Macrobid, Macrodantin
Drug Type
Small Molecule
Chemical Formula
C8H6N4O5
CAS Number
67-20-9
Unique Ingredient Identifier
927AH8112L
Background

Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on many targets at once. Nitrofurantoin is a second line treatment to trimethoprim/sulfamethoxazole.

Nitrofurantoin was granted FDA approval on 6 February 1953.

Indication

Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.

Associated Conditions
Acute Cystitis, Urinary Tract Infection
Clinical Trials
Related News

Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery

Not Applicable
Active, not recruiting
Conditions
Urinary Tract Infections
Pelvic Organ Prolapse
Urinary Incontinence
Interventions
First Posted Date
2018-05-14
Last Posted Date
2023-08-28
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
142
Registration Number
NCT03522961
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis

Phase 2
Completed
Conditions
Cystitis
Uncomplicated Urinary Tract Infection
Interventions
First Posted Date
2018-02-07
Last Posted Date
2020-06-09
Lead Sponsor
Paratek Pharmaceuticals Inc
Target Recruit Count
225
Registration Number
NCT03425396
Locations
🇺🇸

Site 101, La Mesa, California, United States

🇺🇸

Site 102, DeLand, Florida, United States

🇺🇸

Site 114, Aventura, Florida, United States

and more 20 locations

INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI

Phase 4
Withdrawn
Conditions
Urinary Tract Infections
Interventions
First Posted Date
2017-10-03
Last Posted Date
2019-06-06
Lead Sponsor
Mayo Clinic
Registration Number
NCT03299387

Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery

Phase 4
Completed
Conditions
Catheter-Associated Urinary Tract Infection
Interventions
Drug: Placebo Oral Tablet
First Posted Date
2017-09-19
Last Posted Date
2022-08-09
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
164
Registration Number
NCT03287089
Locations
🇺🇸

Atrium Health, Charlotte, North Carolina, United States

Treatment of Asymptomatic Bacteriuria in Pregnancy

Not Applicable
Terminated
Conditions
Bacteriuria (Asymptomatic) in Pregnancy
Interventions
First Posted Date
2016-09-22
Last Posted Date
2018-04-18
Lead Sponsor
Saint Joseph Mercy Health System
Target Recruit Count
13
Registration Number
NCT02911662
Locations
🇺🇸

St. Joseph Mercy Hospital, Ypsilanti, Michigan, United States

Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2

Not Applicable
Completed
Conditions
Sepsis
Urinary Tract Infection (UTI)
Nephrolithiasis
Interventions
Drug: Gentamicin, 5mg/kg
Drug: Gentamicin, 80 mg, 7d
Drug: Gentamicin, 80 mg, 48hr
First Posted Date
2016-07-12
Last Posted Date
2025-03-06
Lead Sponsor
University of California, San Diego
Target Recruit Count
330
Registration Number
NCT02829060
Locations
🇺🇸

University of California San Diego, San Diego, California, United States

The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy

Early Phase 1
Conditions
Complication of Surgical Procedure
Interventions
First Posted Date
2016-06-03
Last Posted Date
2019-10-01
Lead Sponsor
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Target Recruit Count
150
Registration Number
NCT02789579
Locations
🇨🇳

Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine.Kongjiang Road 1665,, Shanghai, Shanghai, China

Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery

Phase 4
Completed
Conditions
Pelvic Organ Prolapse
Interventions
Drug: Placebo
First Posted Date
2016-04-04
Last Posted Date
2019-05-29
Lead Sponsor
Halina M Zyczynski, MD
Target Recruit Count
154
Registration Number
NCT02727322
Locations
🇺🇸

Georgetown/MedStar Hospital Center, Washington, District of Columbia, United States

🇺🇸

Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

First Posted Date
2015-03-10
Last Posted Date
2019-08-22
Lead Sponsor
University of California, San Diego
Target Recruit Count
86
Registration Number
NCT02384200
Locations
🇺🇸

Mayo Clinic in Arizona, Phoenix, Arizona, United States

🇺🇸

UCSD Medical Center, San Diego, California, United States

🇺🇸

The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

and more 5 locations

Struvite Stones Antibiotic Study

Phase 4
Conditions
Kidney Stones
Interventions
First Posted Date
2015-03-02
Last Posted Date
2022-05-17
Lead Sponsor
University of British Columbia
Target Recruit Count
28
Registration Number
NCT02375295
Locations
🇺🇸

Cleveland Clinic Foundation, Cleveland, Ohio, United States

🇺🇸

Mayo Clinic - Scottsdale/Phoenix, AZ, Scottsdale, Arizona, United States

🇺🇸

University California San Diego, San Diego, California, United States

and more 9 locations
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