Nitrofurantoin
- Generic Name
- Nitrofurantoin
- Brand Names
- Furadantin, Macrobid, Macrodantin
- Drug Type
- Small Molecule
- Chemical Formula
- C8H6N4O5
- CAS Number
- 67-20-9
- Unique Ingredient Identifier
- 927AH8112L
- Background
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on man...
- Indication
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.
- Associated Conditions
- Acute Cystitis, Urinary Tract Infection
- Associated Therapies
- -
Efficacy and Safety of Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infections in Adults
- First Posted Date
- 2010-03-24
- Last Posted Date
- 2010-03-24
- Lead Sponsor
- Mepha Ltd.
- Target Recruit Count
- 37
- Registration Number
- NCT01092351
- Locations
- 🇲🇽
Cif Biotec, Medica Sur, Mexico City, Mexico
Does Treatment With Macrobid Reduce Urinary Tract Infections in Patients Receiving a Sub-Urethral Sling for Incontinence
- First Posted Date
- 2008-08-14
- Last Posted Date
- 2016-10-11
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 161
- Registration Number
- NCT00734968
- Locations
- 🇺🇸
Scott and White Hosptial, Texas A&M University, Temple, Texas, United States
Nitrofurantoin and Urinary Tract Infections (UTIs)
- Conditions
- Interventions
- First Posted Date
- 2008-05-15
- Last Posted Date
- 2016-09-27
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 10
- Registration Number
- NCT00678041
- Locations
- 🇺🇸
Magee Womens Hospital, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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