Nitrofurantoin
- Generic Name
- Nitrofurantoin
- Brand Names
- Furadantin, Macrobid, Macrodantin
- Drug Type
- Small Molecule
- Chemical Formula
- C8H6N4O5
- CAS Number
- 67-20-9
- Unique Ingredient Identifier
- 927AH8112L
- Background
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on many targets at once. Nitrofurantoin is a second line treatment to trimethoprim/sulfamethoxazole.
Nitrofurantoin was granted FDA approval on 6 February 1953.
- Indication
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.
- Associated Conditions
- Acute Cystitis, Urinary Tract Infection
Antibiotic Prophylaxis for Clean Intermittent Catheterisation
- Conditions
- Urinary Tract Infections, Recurrent
- Interventions
- Other: No prophylaxis
- First Posted Date
- 2014-05-22
- Last Posted Date
- 2018-03-30
- Lead Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
- Target Recruit Count
- 404
- Registration Number
- NCT02145338
- Locations
- 🇬🇧
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
- Conditions
- Renal Hypodysplasia, Nonsyndromic, 1Vesicoureteral RefluxChronic Kidney Disease
- Interventions
- Other: No prophylaxisDrug: Amoxicillin-Potassium Clavulanate CombinationDrug: Trimethoprim/sulfamethoxazole
- First Posted Date
- 2013-12-27
- Last Posted Date
- 2023-09-28
- Target Recruit Count
- 292
- Registration Number
- NCT02021006
- Locations
- 🇮🇹
Pediatric Nephrology Dialysis and Transplant Unit IRCCS Ca'Granda, Milan, Italy
Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women
- First Posted Date
- 2013-10-21
- Last Posted Date
- 2017-05-02
- Lead Sponsor
- University Hospital, Geneva
- Target Recruit Count
- 600
- Registration Number
- NCT01966653
- Locations
- 🇮🇱
Tel Aviv University, Tel Aviv, Israel
🇵🇱Lodz University Hospital, Lodz, Poland
🇨🇭University Hospitals of Geneva, Geneva, Switzerland
A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department
- Conditions
- Uncomplicated Bacterial Cystitis
- Interventions
- First Posted Date
- 2012-12-13
- Last Posted Date
- 2017-05-31
- Lead Sponsor
- University of Iowa
- Target Recruit Count
- 35
- Registration Number
- NCT01749605
- Locations
- 🇺🇸
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
Examination of the Efficacy of Preventive Antibiotic Treatment During the Puerperium Among Pregnant Women With Recurrent Urinary Tract Infections
- Conditions
- Pregnancy Complications
- Interventions
- Drug: Preventive antibiotic treatment- CEPHALEXINDrug: PREVENTIVE TREATMENT- CEFUROXIMEDrug: PREVENTIVE TREATMENT SULFAMETHOXAZOLE AND TRIMETHOPRIM
- First Posted Date
- 2012-01-11
- Last Posted Date
- 2020-05-19
- Lead Sponsor
- HaEmek Medical Center, Israel
- Target Recruit Count
- 220
- Registration Number
- NCT01507974
- Locations
- 🇮🇱
Dep of OG/GYN, Emek Medical Center, Afula, Israel
Suppressive Therapy With Oral Antibiotics for Prevention of Postoperative Urinary Tract Infection (UTI)
- First Posted Date
- 2011-10-12
- Last Posted Date
- 2017-02-13
- Lead Sponsor
- Duke University
- Target Recruit Count
- 163
- Registration Number
- NCT01450800
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Efficacy and Safety of Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infections in Adults
- First Posted Date
- 2010-03-24
- Last Posted Date
- 2010-03-24
- Lead Sponsor
- Mepha Ltd.
- Target Recruit Count
- 37
- Registration Number
- NCT01092351
- Locations
- 🇲🇽
Cif Biotec, Medica Sur, Mexico City, Mexico
Fed Study of Mylan Nitrofurantoin Monohydrate/Macrocrystals Capsules 100 mg and Macrobid® Capsules 100 mg
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2009-11-23
- Last Posted Date
- 2024-04-23
- Lead Sponsor
- Mylan Pharmaceuticals Inc
- Target Recruit Count
- 80
- Registration Number
- NCT01018342
- Locations
- 🇺🇸
Kendle International Inc., Morgantown, West Virginia, United States
Bioequivalence Study of Nitrofurantoin 100 mg Capsules Under Fed Conditions
- First Posted Date
- 2008-10-23
- Last Posted Date
- 2008-10-23
- Lead Sponsor
- Ranbaxy Laboratories Limited
- Target Recruit Count
- 40
- Registration Number
- NCT00778583
- Locations
- 🇮🇳
Ranbaxy Research Laboratories, Gurgaon, Haryana, India
Does Treatment With Macrobid Reduce Urinary Tract Infections in Patients Receiving a Sub-Urethral Sling for Incontinence
- First Posted Date
- 2008-08-14
- Last Posted Date
- 2016-10-11
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 161
- Registration Number
- NCT00734968
- Locations
- 🇺🇸
Scott and White Hosptial, Texas A&M University, Temple, Texas, United States
Drug Development Updates
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