Nimesulide
- Generic Name
- Nimesulide
- Drug Type
- Small Molecule
- Chemical Formula
- C13H12N2O5S
- CAS Number
- 51803-78-2
- Unique Ingredient Identifier
- V4TKW1454M
- Background
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
- Indication
For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
- Associated Conditions
- Acute Pain, Menstrual Distress (Dysmenorrhea), Pain
- Associated Therapies
- NSAIDs
Phase 2 Study of CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Relapsed and/or Refractory Metastatic Colorectal Cancer
- Conditions
- Metastatic Colorectal Cancer
- Interventions
- First Posted Date
- 2023-09-15
- Last Posted Date
- 2023-09-15
- Lead Sponsor
- Holy Stone Healthcare Co., Ltd
- Target Recruit Count
- 100
- Registration Number
- NCT06039202
Individual Patient Expanded Access to CA102N
- Conditions
- Advanced or Metastatic Colorectal Cancer (mCRC)
- First Posted Date
- 2022-03-10
- Last Posted Date
- 2023-02-27
- Lead Sponsor
- Holy Stone Healthcare Co., Ltd
- Registration Number
- NCT05274204
Comparative Analysis of the Effectiveness of the Use of Nimesulide and CBD Oil in Patients With Pain in the Preauricular Region Due to the Pain-dysfunctional Syndrome of the Temporomandibular Joint.
- Conditions
- Temporomandibular Joint DisordersTemporomandibular Joint Dysfunction SyndromeTemporomandibular Joint Pain
- Interventions
- First Posted Date
- 2020-10-30
- Last Posted Date
- 2021-01-29
- Lead Sponsor
- Pomeranian Medical University Szczecin
- Target Recruit Count
- 30
- Registration Number
- NCT04609748
- Locations
- 🇵🇱
Chair and Depratment of Dental Prosthetics, Szczecin, Poland
First-in-human Study of CA102N Monotherapy and CA102N Combined With Trifluridine/Tipiracil (LONSURF) in Subjects With Advanced Solid Tumors
- Conditions
- Advanced or Metastatic Colorectal Cancer (mCRC)Advanced or Metastatic Solid Tumors
- Interventions
- First Posted Date
- 2018-08-06
- Last Posted Date
- 2022-09-21
- Lead Sponsor
- Holy Stone Healthcare Co., Ltd
- Target Recruit Count
- 37
- Registration Number
- NCT03616574
- Locations
- 🇺🇸
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
🇺🇸Banner MD Anderson Cancer Center, Gilbert, Arizona, United States
🇺🇸MD Anderson Cancer Center, Houston, Texas, United States
Low Level Laser Therapy in the Treatment of Temporomandibular Joint Disorders (TMJDs) Related Pain
- Conditions
- Temporomandibular Joint Disorders
- Interventions
- Device: B-Cure® diode laserDevice: B-Cure® diode laser sham device
- First Posted Date
- 2017-04-18
- Last Posted Date
- 2017-04-18
- Lead Sponsor
- University of Roma La Sapienza
- Target Recruit Count
- 90
- Registration Number
- NCT03119324
Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis
- First Posted Date
- 2014-09-01
- Last Posted Date
- 2014-09-01
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 128
- Registration Number
- NCT02229747
Bioequivalence Study of Nimesulide 100 mg Tablets
- First Posted Date
- 2012-12-10
- Last Posted Date
- 2017-06-12
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 28
- Registration Number
- NCT01745614
Evaluation of Two Therapies for the Treatment of Osteoarticular Inflammation in Dyspeptic Patients
- Conditions
- Acute and Chronic InflammationDyspepsia
- Interventions
- First Posted Date
- 2012-08-22
- Last Posted Date
- 2019-04-17
- Lead Sponsor
- EMS
- Target Recruit Count
- 490
- Registration Number
- NCT01670552
- Locations
- 🇧🇷
Allegisa, Campinas, São Paulo, Brazil
A Prevention Trial in Subjects at High Risk for Breast Cancer
- First Posted Date
- 2011-12-28
- Last Posted Date
- 2014-06-18
- Lead Sponsor
- European Institute of Oncology
- Target Recruit Count
- 150
- Registration Number
- NCT01500577
- Locations
- 🇮🇹
European Institute of Oncology, Milan, Italy
Efficacy of Diclofenac Potassium vs Nimesulide in the Treatment of Fever and Pain in Children With Upper Respiratory Tract Infection
- Conditions
- Upper Respiratory Tract Infections
- Interventions
- First Posted Date
- 2010-12-09
- Last Posted Date
- 2012-04-26
- Lead Sponsor
- Novartis Pharmaceuticals
- Registration Number
- NCT01257126
Drug Development Updates
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