Carvedilol
- Generic Name
- Carvedilol
- Brand Names
- Coreg
- Drug Type
- Small Molecule
- Chemical Formula
- C24H26N2O4
- CAS Number
- 72956-09-3
- Unique Ingredient Identifier
- 0K47UL67F2
- Background
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. It is currently used to treat heart failure, left ventricular dysfunction, and hypertension. The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs ...
- Indication
Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.
- Associated Conditions
- Atrial Fibrillation, Chronic Stable Angina Pectoris, Hypertension, LVEF ≤40% Left ventricular dysfunction, NYHA Class I or II heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV)
- Associated Therapies
- -
Acute Hemodynamic Response to Carvedilol in Children With Clinically Significant Portal Hypertension.
- First Posted Date
- 2023-03-14
- Last Posted Date
- 2024-05-09
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 40
- Registration Number
- NCT05767229
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India
Carvedilol vs. Propranolol in Second Prophylaxis of Variceal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2022-12-15
- Last Posted Date
- 2022-12-15
- Lead Sponsor
- West China Hospital
- Target Recruit Count
- 160
- Registration Number
- NCT05651789
Carvedilol in HF With Preserved EF
- Conditions
- Interventions
- First Posted Date
- 2022-09-23
- Last Posted Date
- 2023-11-08
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT05553314
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Il-won, Korea, Republic of
🇰🇷Wonju Severance Christian Hospital, Wonju, Korea, Republic of
Clinical Study Evaluating the Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy
- Conditions
- Interventions
- First Posted Date
- 2022-09-23
- Last Posted Date
- 2022-09-23
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 66
- Registration Number
- NCT05553717
Effect of Carvedilol Rapid Up-Titration in Patients With Heart Failure With Reduced Ejection Fraction
- First Posted Date
- 2022-01-05
- Last Posted Date
- 2022-01-05
- Lead Sponsor
- Universitas Sebelas Maret
- Target Recruit Count
- 26
- Registration Number
- NCT05179070
- Locations
- 🇮🇩
Universitas Sebelas Maret Hospital, Sukoharjo, Central Of Java, Indonesia
Efficacy and Safety of Carvedilol in Cirrhosis Patients With Uncomplicated Ascites Without High Risk Esophageal Varices
- Conditions
- Interventions
- First Posted Date
- 2021-09-27
- Last Posted Date
- 2021-10-28
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 120
- Registration Number
- NCT05057572
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India
Are Carvedilol and Metoprolol Succinate Comparable Treatments in Heart Failure Patients With Reduced Ejection Fraction
- Conditions
- Interventions
- First Posted Date
- 2021-08-09
- Last Posted Date
- 2021-08-16
- Lead Sponsor
- Odense University Hospital
- Target Recruit Count
- 5600
- Registration Number
- NCT04996550
- Locations
- 🇩🇰
Department of Cardiology, Odense University Hospital, Odense, Region Of Southern Denmark, Denmark
Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy
- First Posted Date
- 2021-06-25
- Last Posted Date
- 2024-06-28
- Lead Sponsor
- Hospital Sirio-Libanes
- Target Recruit Count
- 1018
- Registration Number
- NCT04939883
- Locations
- 🇧🇷
Hospital Sirio Libanes, São Paulo, Sao Paulo, Brazil
Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis
- Conditions
- Interventions
- First Posted Date
- 2020-09-10
- Last Posted Date
- 2021-10-25
- Lead Sponsor
- Tianjin Second People's Hospital
- Target Recruit Count
- 288
- Registration Number
- NCT04543643
- Locations
- 🇨🇳
Tianjin Second People's Hospital, Tianjin, Tianjin, China
Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2020-08-05
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Sherief Abd-Elsalam
- Target Recruit Count
- 306
- Registration Number
- NCT04499898
- Locations
- 🇪🇬
Sherief Abd-Elsalam, Tanta, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.