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Dapivirine

Generic Name
Dapivirine
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C20H19N5
CAS Number
244767-67-7
Unique Ingredient Identifier
TCN4MG2VXS
Background

Dapivirine has been investigated for the prevention of HIV-1 Infections and Topical Penile Exposures.

Associated Conditions
-
Associated Therapies
-
Clinical Trials
Related News

Safety and Drug Detection Study of Dapivirine Vaginal Ring and Oral TRUVADA® in Breastfeeding Mother-Infant Pairs

Phase 3
Completed
Conditions
HIV Infections
Interventions
Drug: Truvada Tablet
Drug: Dapivirine (DPV) Vaginal Ring (VR)-004
First Posted Date
2019-10-25
Last Posted Date
2023-08-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
394
Registration Number
NCT04140266
Locations
🇺🇬

MU-JHU Research Collaboration (MUJHU CARE LTD) CRS, Kampala, Uganda

🇲🇼

Blantyre CRS (Johns Hopkins Research Project/College of Medicine), Blantyre, Malawi

🇿🇼

Zengeza CRS, Chitungwiza, Mashonaland East, Zimbabwe

and more 1 locations

Randomized, Open Label Safety Trial of Dapivirine Vaginal Ring and Oral TRUVADA® Use in Pregnancy

Phase 3
Completed
Conditions
HIV Infections
Interventions
Drug: Dapivirine (DPV) Vaginal Ring (VR)
Drug: Truvada Tablet
First Posted Date
2019-05-29
Last Posted Date
2024-07-05
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
1105
Registration Number
NCT03965923
Locations
🇺🇬

MU-JHU Research Collaboration (MUJHU CARE LTD) CRS, Kampala, Uganda

🇿🇦

Wits RHI Shandukani Research Centre CRS, Johannesburg, Gauteng, South Africa

🇲🇼

Blantyre CRS (Johns Hopkins Research Project/College of Medicine), Blantyre, Malawi

and more 1 locations

Pharmacokinetic Study of Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults

Phase 1
Completed
Conditions
HIV Infections
Interventions
Drug: Dapivirine gel
First Posted Date
2018-01-08
Last Posted Date
2021-10-25
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
16
Registration Number
NCT03393468
Locations
🇺🇸

University of Pittsburgh CRS, Pittsburgh, Pennsylvania, United States

Safety and Pharmacokinetic Study of Dapivirine Gel (0.05%) Administered Rectally to HIV-1 Seronegative Adults

Phase 1
Completed
Conditions
HIV Infections
Interventions
Drug: Dapivirine gel
Drug: Placebo gel
First Posted Date
2017-08-04
Last Posted Date
2021-10-19
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
28
Registration Number
NCT03239483
Locations
🇺🇸

University of Pittsburgh CRS, Pittsburgh, Pennsylvania, United States

🇹🇭

Silom Community Clinic CRS, Nonthaburi, Bangkok, Thailand

🇺🇸

Alabama CRS, Birmingham, Alabama, United States

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