Rifampicin
- Generic Name
- Rifampicin
- Brand Names
- Isonarif, Rifadin, Rifamate, Rifater, Rofact
- Drug Type
- Small Molecule
- Chemical Formula
- C43H58N4O12
- CAS Number
- 13292-46-1
- Unique Ingredient Identifier
- VJT6J7R4TR
- Background
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericid...
- Indication
Rifampin is indicated for the treatment of tuberculosis and tuberculosis-related mycobacterial infections. In combination with pyrazinamide and isoniazid, it is used in the initial phase of the short-course treatment of pulmonary tuberculosis.
- Associated Conditions
- Cholestatic pruritus, MRSA Infections, Prosthetic Joint Infections, Asymptomatic Neisseria meningitidis carrier of the nasopharynx, Initial phase Tuberculosis, Late phase Tuberculosis
- Associated Therapies
- Antibacterial therapy
Study on Food Influence and Drug-drug Interaction of HLX208 Tablets in Chinese Healthy Subjects
- First Posted Date
- 2023-06-15
- Last Posted Date
- 2024-04-05
- Lead Sponsor
- Shanghai Henlius Biotech
- Target Recruit Count
- 20
- Registration Number
- NCT05902728
- Locations
- 🇨🇳
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Evaluation of the Effect of Rifampin and Rabeprazole on the Pharmacokinetics of Camlipixant
- First Posted Date
- 2023-06-12
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- Bellus Health Inc. - a GSK company
- Target Recruit Count
- 42
- Registration Number
- NCT05899829
- Locations
- 🇨🇦
GSK Investigational Site, Quebec City, Quebec, Canada
A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2023-04-24
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- Insmed Incorporated
- Target Recruit Count
- 32
- Registration Number
- NCT05826574
- Locations
- 🇺🇸
USA001, Dallas, Texas, United States
PanACEA - STEP2C -01
- Conditions
- Interventions
- First Posted Date
- 2023-04-11
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- Michael Hoelscher
- Target Recruit Count
- 270
- Registration Number
- NCT05807399
- Locations
- 🇲🇼
Kamuzu College of Health Sciences (formerly College of Medicine), Blantyre, Malawi
🇹🇿Kilimanjaro Clinical Research Institute (KCRI), Moshi, Tanzania
🇺🇬Makerere University Lung Institute Limited, Kampala, Uganda
Short-course Regimens for the Treatment of Pulmonary Tuberculosis
- First Posted Date
- 2023-03-13
- Last Posted Date
- 2024-01-08
- Lead Sponsor
- Centers for Disease Control and Prevention
- Target Recruit Count
- 288
- Registration Number
- NCT05766267
- Locations
- 🇺🇸
TBTC Site 26 Seattle & King County TB Control Program, Seattle, Washington, United States
🇺🇸TBTC Site 64A New York City Department of Health and Mental Hygiene- Corona Chest Center, Jackson Heights, New York, United States
🇺🇸TBTC Site 63 San Antonio VA Medical Center (South Texas Group), San Antonio, Texas, United States
HMPL-523 CYP3A/P-gp Inhibitor and CYP Inducer Study
- Conditions
- Interventions
- First Posted Date
- 2023-02-09
- Last Posted Date
- 2023-03-01
- Lead Sponsor
- Hutchmed
- Target Recruit Count
- 28
- Registration Number
- NCT05720767
- Locations
- 🇺🇸
PPD Austin, Austin, Texas, United States
A Study to Evaluate the Relative Bioavailability of STI-1558 and the Effect of Itraconazole and Rifampin on the Pharmacokinetics of STI-1558
- Conditions
- Interventions
- First Posted Date
- 2023-01-17
- Last Posted Date
- 2023-12-07
- Lead Sponsor
- Zhejiang ACEA Pharmaceutical Co. Ltd.
- Target Recruit Count
- 37
- Registration Number
- NCT05685719
- Locations
- 🇨🇳
Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China
Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants
- First Posted Date
- 2022-12-02
- Last Posted Date
- 2024-03-20
- Lead Sponsor
- Vertex Pharmaceuticals Incorporated
- Target Recruit Count
- 31
- Registration Number
- NCT05635110
- Locations
- 🇦🇺
CMAX Clinical Research, Adelaide, Australia
Phase I Open Label BCG Clinical Trial Assessing TB Drugs and Vaccines
- Conditions
- Interventions
- First Posted Date
- 2022-10-24
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- Fred Hutchinson Cancer Center
- Target Recruit Count
- 20
- Registration Number
- NCT05592223
- Locations
- 🇺🇸
Fred Hutchinson Cancer Center, Seattle, Washington, United States
A Study to Evaluate the Drug-drug Interaction Effect of Rifampin on the Pharmacokinetics of AMG 510 in Healthy Participants
- First Posted Date
- 2022-10-13
- Last Posted Date
- 2024-11-21
- Lead Sponsor
- Amgen
- Target Recruit Count
- 14
- Registration Number
- NCT05577624
- Locations
- 🇺🇸
Covance Clinical Research Unit, Inc 3402 Kinsman Boulevard, Madison, Wisconsin, United States
Drug Development Updates
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