Chlorthalidone
- Generic Name
- Chlorthalidone
- Brand Names
- Edarbyclor, Tenoretic, Thalitone
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11ClN2O4S
- CAS Number
- 77-36-1
- Unique Ingredient Identifier
- Q0MQD1073Q
- Background
Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in t...
- Indication
Chlorthalidone is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy....
- Associated Conditions
- Calcium Nephrolithiasis, Edema, Hypertension
- Associated Therapies
- -
Comparison of Optimal Hypertension Regimens
- Conditions
- Interventions
- First Posted Date
- 2016-07-28
- Last Posted Date
- 2021-07-28
- Target Recruit Count
- 1320
- Registration Number
- NCT02847338
- Locations
- 🇬🇧
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
🇬🇧University Hospital Llandough, Cardiff, United Kingdom
🇬🇧Queen Elizabeth Hospital, Birmingham, United Kingdom
Chlorthalidone in Chronic Kidney Disease
- Conditions
- Interventions
- First Posted Date
- 2016-07-22
- Last Posted Date
- 2023-05-15
- Lead Sponsor
- Indiana University
- Target Recruit Count
- 160
- Registration Number
- NCT02841280
- Locations
- 🇺🇸
Indiana University School of Medicine, Division of Nephrology, Indianapolis, Indiana, United States
Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium
- Conditions
- Interventions
- First Posted Date
- 2016-03-17
- Last Posted Date
- 2023-04-27
- Lead Sponsor
- VA New York Harbor Healthcare System
- Target Recruit Count
- 10
- Registration Number
- NCT02711670
- Locations
- 🇺🇸
VA New York Harbor Healthcare System, New York, New York, United States
Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate
- Conditions
- Interventions
- First Posted Date
- 2016-01-27
- Last Posted Date
- 2023-10-25
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 61
- Registration Number
- NCT02665117
- Locations
- 🇺🇸
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States
🇺🇸UT Southwestern Medical Center, Dallas, Texas, United States
🇺🇸University of Texas Southwestern Medical Center, Dallas, Texas, United States
Thiazide Diuretics for Hypertension in Kidney Transplant Recipients Using Tacrolimus
- Conditions
- Interventions
- First Posted Date
- 2015-12-31
- Last Posted Date
- 2017-06-16
- Lead Sponsor
- Erasmus Medical Center
- Target Recruit Count
- 49
- Registration Number
- NCT02644395
- Locations
- 🇳🇱
ErasmusMC, Rotterdam, Netherlands
Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD
- Conditions
- Interventions
- First Posted Date
- 2015-07-20
- Last Posted Date
- 2018-01-19
- Lead Sponsor
- University Hospital Birmingham
- Target Recruit Count
- 154
- Registration Number
- NCT02502981
- Locations
- 🇬🇧
Royal Free Hospital, London, United Kingdom
🇬🇧Departments of Cardiology & Nephrology University Hospital Birmingham, Birmingham, West Midlands, United Kingdom
🇬🇧University of Edinburgh: BHF Centre for Cardiovascular Science and Western General Hospital, Edinburgh, United Kingdom
Mechanisms of Refractory Hypertension (Carvedilol)
- First Posted Date
- 2015-02-06
- Last Posted Date
- 2020-06-12
- Lead Sponsor
- University of Alabama at Birmingham
- Registration Number
- NCT02357004
Tissue Sodium in Pre-hypertensive Patients
- Conditions
- Interventions
- First Posted Date
- 2014-09-10
- Last Posted Date
- 2019-05-22
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 71
- Registration Number
- NCT02236520
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)
- Conditions
- Interventions
- First Posted Date
- 2014-06-02
- Last Posted Date
- 2014-11-19
- Lead Sponsor
- Yuhan Corporation
- Target Recruit Count
- 66
- Registration Number
- NCT02152969
- Locations
- 🇰🇷
The Catholic University of Korea Seoul St.Mary's Hospital, Seoul, Korea, Republic of
Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2014-04-23
- Last Posted Date
- 2017-02-10
- Lead Sponsor
- Anthony J Viera, MD, MPH
- Target Recruit Count
- 28
- Registration Number
- NCT02121041
- Locations
- 🇺🇸
University of North Carolina, Chapel Hill, North Carolina, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.